The effects of brain-derived neurotrophic factor (BDNF) on cocaine-seeking are brain region-specific.
Infusion of BDNF into subcortical structures, like the nucleus accumbens and …

The medial prefrontal cortex (mPFC) is critical for reinstatement of cocaine seeking and is
the main source of brain‐derived neurotrophic factor (BDNF) to striatal regions of the brain …

Antisera raised against synthetic dynorphin or [Leu5]enkephalin demonstrate immunostaining
in hippocampal mossy fibers and in dentate granule cells. However, dynorphin …

The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting
to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that …

The impact of cocaine self-administration on the expression of striatal preprodynorphin and
c-fos mRNA was examined with in situ hybridization histochemistry. Cocaine significantly …

Chronic methamphetamine (meth) abuse can lead to persisting cognitive deficits. Here, we
utilized a long-access meth self-administration (SA) protocol to assess recognition memory …

Chronic abuse of methamphetamine leads to cognitive dysfunction and high rates of relapse,
paralleled by significant changes of brain dopamine and serotonin neurotransmission. …

Cocaine-mediated neuroadaptations in the prefrontal cortical-nucleus accumbens pathway
underlie drug-seeking in animals with a cocaine self-administration (SA) history. …

Background Excessive ethanol (EtOH) consumption remains an important health concern and
effective treatments are lacking. The central oxytocin system has emerged as a potentially …

Suppression of dangerous or inappropriate reward-motivated behaviors is critical for survival,
whereas therapeutic or recreational opioid use can unleash detrimental behavioral actions …