[PDF][PDF] pH-dependent structural transitions of Alzheimer amyloid peptides

PE Fraser, JT Nguyen, WK Surewicz, DA Kirschner - Biophysical journal, 1991 - cell.com
To understand the molecular interactions leading to the assembly of beta/44 protein into the
hallmark fibrils of Alzheimer's disease (AD), we have examined the ability of synthetic …

Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors

JT Nguyen, CW Turck, FE Cohen, RN Zuckermann… - Science, 1998 - science.org
Src homology 3 (SH3) and WW protein interaction domains bind specific proline-rich
sequences. However, instead of recognizing critical prolines on the basis of side chain shape or …

Discovery of an allosteric site in the caspases

…, J Lam, JT Nguyen, T O'Brien… - Proceedings of the …, 2004 - National Acad Sciences
Allosteric regulation of proteins by conformational change is a primary means of biological
control. Traditionally it has been difficult to identify and characterize novel allosteric sites and …

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid. beta.-protein

PE Fraser, JT Nguyen, H Inouye, WK Surewicz… - Biochemistry, 1992 - ACS Publications
Revised Manuscript Received August 10, 1992 abstract: Deposition of extraneuronal fibrils
that assemble from the 39-43 residue 3/A4 amyloid protein is one of the earliest …

[HTML][HTML] Triple Combination of Amantadine, Ribavirin, and Oseltamivir Is Highly Active and Synergistic against Drug Resistant Influenza Virus Strains In Vitro

JT Nguyen, JD Hoopes, MH Le, DF Smee, AK Patick… - PloS one, 2010 - journals.plos.org
The rapid emergence and subsequent spread of the novel 2009 Influenza A/H1N1 virus (2009
H1N1) has prompted the World Health Organization to declare the first pandemic of the …

Effects of sulfate ions on Alzheimer β/A4 peptide assemblies: implications for amyloid fibril‐proteoglycan interactions

PE Fraser, JT Nguyen, DT Chin… - Journal of …, 1992 - Wiley Online Library
To model the possible involvement of sulfated proteoglycans in amyloidogenesis, we
examined the influence of sulfate ions, heparan, and Congo red on the conformation and …

TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

…, EN Bunker, WM Rosencrans, JT Nguyen… - Molecular Cell, 2023 - cell.com
Mitophagy is a form of selective autophagy that disposes of superfluous and potentially
damage-inducing organelles in a tightly controlled manner. While the machinery involved in …

Modeling amantadine treatment of influenza A virus in vitro

…, JJ McSharry, GL Drusano, JT Nguyen… - Journal of theoretical …, 2008 - Elsevier
We analyzed the dynamics of an influenza A/Albany/1/98 (H3N2) viral infection, using a set
of mathematical models highlighting the differences between in vivo and in vitro infection. For …

X-ray diffraction of scrapie prion rods and PrP peptides

JT Nguyen, H Inouye, MA Baldwin, RJ Fletterick… - Journal of molecular …, 1995 - Elsevier
Certain neurodegenerative diseases in humans and animals are caused by small proteinaceous
infectious particles called prions. Limited proteolysis and detergent extraction of the …

[PDF][PDF] Improving SH3 domain ligand selectivity using a non-natural scaffold

JT Nguyen, M Porter, M Amoui, WT Miller… - Chemistry & biology, 2000 - cell.com
Background: Src homology 3 (SH3) domains bind sequences bearing the consensus motif
PxxP (where P is proline and x is any amino acid), wherein domain specificity is mediated …