Predominant autoantibody production by early human B cell precursors

H Wardemann, S Yurasov, A Schaefer, JW Young… - Science, 2003 - science.org
During B lymphocyte development, antibodies are assembled by random gene segment
reassortment to produce a vast number of specificities. A potential disadvantage of this process …

[HTML][HTML] Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation

…, AP Gillio, TN Small, JW Young… - … England Journal of …, 1994 - Mass Medical Soc
Background Lymphoma associated with Epstein-Barr virus (EBV) is a complication of bone
marrow transplantation that responds poorly to standard forms of therapy. The lymphoma is …

Telomerase activity in normal and malignant hematopoietic cells.

D Broccoli, JW Young… - Proceedings of the …, 1995 - National Acad Sciences
Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain
telomerase activity detectable by a PCR-based assay. Telomerase was also detectable …

[HTML][HTML] Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions

…, E Bonvini, JV Ravetch, JW Young - The Journal of …, 2005 - Am Soc Clin Investig
Human monocyte-derived DCs (moDCs) and circulating conventional DCs coexpress
activating (CD32a) and inhibitory (CD32b) isoforms of IgG Fcγ receptor (FcγR) II (CD32). The …

Adoptive immunotherapy with unselected or EBV-specific T cells for biopsy-proven EBV+ lymphomas after allogeneic hematopoietic cell transplantation

…, TN Small, R Khalaf, JW Young… - Blood, The Journal …, 2012 - ashpublications.org
We evaluated HLA-compatible donor leukocyte infusions (DLIs) and HLA-compatible or HLA-disparate
EBV-specific T cells (EBV-CTLs) in 49 hematopoietic cell transplantation …

Dendritic cells

D Bell, JW Young, J Banchereau - Advances in immunology, 1999 - Elsevier
Publisher Summary This chapter provides an overview of dendritic cells (DCs). Dendritic
cells were first identified in the epidermis and were termed “Langerhans cells.” DCs are now …

Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity

M Rossi, JW Young - The Journal of Immunology, 2005 - journals.aai.org
Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes that are critical to the
development of immunity. Investigators have emphasized the role of DCs in initiating …

Priming of protective T cell responses against virus-induced tumors in mice with human immune system components

…, J Sashihara, G Koo, CM Rice, JW Young… - Journal of Experimental …, 2009 - rupress.org
Many pathogens that cause human disease infect only humans. To identify the mechanisms
of immune protection against these pathogens and also to evaluate promising vaccine …

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

K Inaba, JW Young, RM Steinman - The Journal of experimental …, 1987 - rupress.org
Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes
can be induced to proliferate and become killer cells in the absence of a second population of …

Indoleamine 2, 3-dioxygenase–expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

…, J Ghith, J Yuan, DH Munn, JW Young - Blood, The Journal …, 2009 - ashpublications.org
A comprehensive understanding of the complex, autologous cellular interactions and regulatory
mechanisms that occur during normal dendritic cell (DC)–stimulated immune responses …