The contribution of oxidative stress to ischemic brain damage is well established. Nevertheless,
for unknown reasons, several clinically tested antioxidant therapies have failed to show …

To assess the importance of brain cytochrome P450 (P450) activity in μ opioid analgesic
action, we generated a mutant mouse with brain neuron–specific reductions in P450 activity; …

Previous studies have suggested a possible pain-modulatory role for histamine H 3 receptors,
but the localization of these receptors and nature of this modulation is not clear. In order to …

… Consistent with our pharmacological results (Hough and Nalwalk 1992a; and Figs. 4-51,
autoradiographic studies have identified HZ receptors in the mesencephalic central grey of the …

Respiratory depression is a therapy-limiting side effect of opioid analgesics, yet our
understanding of the brain circuits mediating this potentially lethal outcome remains incomplete. …

The ubiquitous volume-regulated anion channels (VRACs) facilitate cell volume control and
contribute to many other physiological processes. Treatment with non-specific VRAC …

Burimamide, a histamine (HA) derivative with both H 2 ‐ and H 3 ‐blocking properties, induces
antinociception when injected into the rodent CNS. Several related compounds share this …

… Author links open overlay panel LB Hough a , JW Nalwalk a , Y. Chen a , A. Schuller b , Y. …
BY Li, JW Nalwalk, JM Finkel, SD Glick, LB Hough … BY Li, JW Nalwalk, LB Hough …

The occurrence of recurrent, unprovoked seizures is the hallmark of human epilepsy.
Currently, only two-thirds of this patient population has adequate seizure control. New epilepsy …

GT-2016, a non-thiourea-containing imidazole, has been developed as a histamine H3
antagonist. In vitro and in vivo studies in rats were conducted to characterize receptor selectivity …