Background: Per- and polyfluoroalkyl substances (PFAS) are a large class of synthetic (man-made)
chemicals widely used in consumer products and industrial processes. Thousands of …

Liver disease is a major health issue characterized by several pathological changes, with
steatosis (fatty liver) representing a common initial step in its pathogenesis. Steatosis is of …

Background: Per- and polyfluoroalkyl substances (PFAS) encompass a class of chemically
and structurally diverse compounds that are extensively used in industry and detected in the …

Exposure to arsenic via drinking water is a serious health concern in the US. Whereas
studies have identified arsenic alone as an independent risk factor for liver disease, …

Plasminogen activator inhibitor-1 (PAI-1) is an acute phase protein that has been shown to
play a role in experimental fibrosis caused by bile duct ligation (BDL) in mice. However, its …

Background Systematic evidence maps (SEMs) are gaining visibility in environmental
health for their utility to serve as problem formulation tools and assist in decision-making, …

Studies in rodents suggest that the adipocytokine resistin causes insulin resistance via
impairing normal insulin signaling. However, in humans, resistin may play a more important role …

It is well known that ethanol preexposure sensitizes the liver to LPS hepatotoxicity. The
mechanisms by which ethanol enhances LPS-induced liver injury are not completely elucidated …

… Phillip Kaiser a , Juliane I. Beier a , Jun Zhang b , … J. Phillip Kaiser was supported by a
predoctoral (F31) fellowship from the National Institute of Alcohol Abuse and Alcoholism (…

Systematic evidence maps (SEMs) are increasingly used to inform decision-making and risk
management priority-setting and to serve as problem formulation tools to refine the focus of …