Iodinated 3,5-Diaminobenzoic Acid Derivatives1

…, J Sprague, B Cloke, J Moss, JO Hoppe - Journal of the …, 1956 - ACS Publications
Method A. Formylation Using Excess Dimethylformamide.—Seventy-seven grams (0.5 mole)
of phosphorusoxy-chloride was added dropwise xvith stirring and cooling to 146 g.(2moles) …

Observations on the toxicity of a new urographic contrast medium, sodium 3, 5-diacetamido-2, 4, 6-triiodobenzoate (hypaquesodium) and related compounds

JO Hoppe, AA Larsen, F Coulston - Journal of Pharmacology and …, 1956 - ASPET
Observations on the acute intravenous toxicity of a series of 3, 5-diacylamino-2,4,6-triiodobenzoic
acids in mice were presented. The least toxic compound of this series was found to be …

Amino-and ammonium-alkylaminobenzoquinones as curarimimetic agents

CJ Cavallito, AE Soria, JO Hoppe - Journal of The American …, 1950 - ACS Publications
The acid-catalyzed methanolysis and hydrolysis of 2, 2-dimethyl-l-(3-aminopropyl)-ethyleneimine
led in each case to cleavage of the bond between the tertiary carbon and the nitrogen …

1-Ethyl-4-(3-tropanyl)-tetrahydro-1H-1, 4-benzodiazepine

…, TR Lewis, MJ Unser, JO Hoppe… - Journal of the …, 1957 - ACS Publications
At the time our work had started central vasodepressive action of quaternary ammonium
salts had not been demonstrated, but in the course of our studies, Cavallito and O’Dell found …

Use of the trypan blue and rabbit eye tests for irritation

JO Hoppe, EB Alexander, LC Miller - Journal of the American …, 1950 - Elsevier
An objective method has been described for determining the irritant properties of
substances designed for parenteral administration by means of the trypan blue test. Various …

The pharmacology and toxicology of mepivacaine, a new local anesthetic

FP Luduena, JO Hoppe, F Coulston… - Toxicology and Applied …, 1960 - Elsevier
The local anesthetic activity, toxicity, and irritancy of mepivacaine HCl 1 (1-methyl-2′,6′-pipecoloxylidide
hydrochloride) and a solution (solution B) containing 2.0% mepivacaine HCl …

X-ray contrast media for cardiovascular angiography

JO Hoppe, S Archer - Angiology, 1960 - journals.sagepub.com
The search for a means of visualizing the chambers of the heart and the blood vessels on x-ray
film began almost simultaneously with the discovery of cholecystography and the develop…

A pharmacological investigation of 2, 5-bis-(3-diethyl-aminopropylamino) benzoquinone-bis-benzylchloride (WIN 2747): a new curarimimetic drug

JO Hoppe - Journal of Pharmacology and Experimental …, 1950 - ASPET
1. WIN 2747 produced complete arrest of nerve-impulse transmission in the dog nerve-muscle
preparation at dosages approximately one-half the dose of d-tubocurarine chloride …

Antihypertensive activity of 7-azaindole-3-acetamidoxime and indole-1-acetamidoxime

MR Bell, JO Hoppe, HE Lape, D Wood, A Arnold… - Experientia, 1967 - Springer
7-Azaindol-3-acetamidoxim (I) und Indol-1-acetamidoxim (II) normalisieren hohen Blutdruck
von Ratten und Hunden. Die blutdrucksenkende Wirkung von I scheint auf der Freisetzung …

An investigation of the structure-activity correlations within a series of ambenonium analogs

AM Lands, JO Hoppe, A Arnold, FK Kirchner - Journal of Pharmacology and …, 1958 - ASPET
Inhibition of AChE has been demonstrated with ambenonium and related compounds. The
structure of the ammonium group shows highly specific requirements for optimum activity. …