Brain injury generates the release of a multitude of factors including extracellular nucleotides,
which exhibit bi-functional properties and contribute to both detrimental actions in the …

… (J and K) P2X7R immunostaining in hippocampus from PBS (J) or BBG (K) treated J20 mice.
Scale bar, 500 μm. (L–O) Confocal images of hippocampus immunolabeled with antibodies …

Diadenosine polyphosphates are a family of naturally occurring nucleotidic compounds present
in secretory vesicles together with other chemical messengers. The exocytotic release of …

Nucleotides can contribute to the survival of different glial and neuronal models at the nervous
system via activation of purinergic P2X and P2Y receptors. Their activation counteracts …

ATP stimulates [Ca 2+ ] i increases in midbrain synaptosomes via specific ionotropic receptors
(P2X receptors). Previous studies have demonstrated the implication of P2X 3 subunits in …

The amyloid precursor protein (APP) is proteolytically processed by β- and γ-secretases to
release amyloid-β peptide (Aβ), the main component found in senile plaques of Alzheimer’s …

The antagonist activity of a series of diinosine polyphosphates (Ip n I, where n=3, 4, 5) was
assessed against ATP‐activated inward currents at rat P2X 1–4 receptors expressed in …

We have tested the hypothesis that neuropathic pain acting as a stressor drives functional
plasticity in the sympathoadrenal system. The relation between neuropathic pain and adrenal …

Diadenosine polyphosphates present at the cytosol can be transported to secretory granules
allowing their exocytotic release. Extracellularly, they can act through specific metabotropic …

… , allows a security threshold in the cellular energetic metabolism (Gualix et al., 1996, 1997). …
out on the nucleotide transporter present in chromaffin granules (Gualix et al., 1996, 1997). …