User profiles for J. E. Friedman

Jacob E. Friedman

University of Oklahoma
Verified email at ucdenver.edu
Cited by 21083

[PDF][PDF] Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes

…, JP Kirwan, PM Catalano, JE Friedman - Diabetes …, 2007 - researchgate.net
… Shao J, Catalano PM, Yamashita H, Ishizuka T, Friedman JE: Vanadate enhances but does
not normalize glucose transport and insulin receptor phosphorylation in skeletal muscle from …

TNF-α is a predictor of insulin resistance in human pregnancy

…, JC Challier, L Huston-Presley, JE Friedman… - Diabetes, 2002 - Am Diabetes Assoc
Historically, insulin resistance during pregnancy has been ascribed to increased production
of placental hormones and cortisol. The purpose of this study was to test this hypothesis by …

[HTML][HTML] The importance of nutrition in pregnancy and lactation: lifelong consequences

…, P Catalano, P Christian, JE Friedman… - American journal of …, 2022 - Elsevier
Most women in the United States do not meet the recommendations for healthful nutrition and
weight before and during pregnancy. Women and providers often ask what a healthy diet …

[HTML][HTML] Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates

…, BE Grayson, MS Smith, JE Friedman… - The Journal of …, 2009 - Am Soc Clin Investig
… to JE Friedman). The authors would like to acknowledge the technical assistance of Lindsay
Pranger, Sandra Joachim, Christopher Osman, Diana Takahashi, and the Division of Animal …

Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

…, MR Miller, LA Barbour, JE Friedman - American Journal of …, 2010 - journals.physiology.org
… Address for reprint requests and other correspondence: JE Friedman, Depts. of Pediatrics,
Biochemistry and Molecular Genetics, Univ. of Colorado School of Medicine, PO Box 6511, …

Small-molecule inhibition of TNF-α

…, ES Day, LA Cruz, TG Cachero, SK Miller, JE Friedman… - Science, 2005 - science.org
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes
subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α …

Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation

…, MN Sack, E Jing, CR Kahn, JE Friedman… - Biochemical …, 2011 - portlandpress.com
Acetylation has recently emerged as an important mechanism for controlling a broad array
of proteins mediating cellular adaptation to metabolic fuels. Acetylation is governed, in part, …

Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes.

JE Friedman, T Ishizuka, J Shao, L Huston… - Diabetes, 1999 - Am Diabetes Assoc
Women who develop gestational diabetes mellitus (GDM) have severe insulin resistance
and markedly increased risk to develop subsequent type 2 diabetes. We investigated the …

Longitudinal changes in maternal serum leptin concentrations, body composition, and resting metabolic rate in pregnancy

TJ Highman, JE Friedman, LP Huston… - American journal of …, 1998 - Elsevier
OBJECTIVE: We sought to evaluate the longitudinal changes in maternal serum leptin
concentrations, body composition, and resting metabolic rate during pregnancy. STUDY DESIGN: …

Downregulated IRS-1 and PPARγ in obese women with gestational diabetes: relationship to FFA during pregnancy

…, L Preston, L Qiao, JE Friedman - American Journal …, 2002 - journals.physiology.org
Gestational diabetes mellitus (GDM) is associated with elevated postprandial free fatty acids
(FFA) and insulin resistance; however, little is known about the cellular mechanisms …