User profiles for J. Craig Rowlands

J Craig Rowlands, PhD, DABT

UL Solutions LLC
Verified email at ul.com
Cited by 5858

[HTML][HTML] Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in …

…, G Camussi, CS Cho, YJ Choi, J Craig Rowlands… - Archives of …, 2013 - Springer
This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested, …

Aryl hydrocarbon receptor-mediated signal transduction

JC Rowlands, JÅ Gustafsson - Critical reviews in toxicology, 1997 - Taylor & Francis
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH)
protein that heterodimerizes with the bHLH protein ARNT (aryl hydrocarbon nuclear …

Incorporating new technologies into toxicity testing and risk assessment: moving from 21st century vision to a data-driven framework

…, MJ Devito, I Cote, JC Rowlands… - toxicological …, 2013 - academic.oup.com
Based on existing data and previous work, a series of studies is proposed as a basis toward
a pragmatic early step in transforming toxicity testing. These studies were assembled into a …

[HTML][HTML] The health consequences of early soy consumption

TM Badger, MJJ Ronis, R Hakkak, JC Rowlands… - The Journal of …, 2002 - Elsevier
Infants fed soy formula are the segment of the US population that consumes the most soy.
Before birth and after weaning, most Americans are not exposed to appreciable levels of …

Risk assessment in the 21st century: roadmap and matrix

…, TP Pastoor, RD Phillips, JC Rowlands… - Critical reviews in …, 2014 - Taylor & Francis
The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven
risk assessment roadmap that takes advantage of existing information to graphically …

A 21st century roadmap for human health risk assessment

…, A Moretto, RD Phillips, JC Rowlands… - Critical reviews in …, 2014 - Taylor & Francis
The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the
21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient …

[HTML][HTML] Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

G Patlewicz, TW Simon, JC Rowlands… - Regulatory Toxicology …, 2015 - Elsevier
An adverse outcome pathway (AOP) describes the causal linkage between initial molecular
events and an adverse outcome at individual or population levels. Whilst there has been …

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

…, EL LeCluyse, RA Budinsky, JC Rowlands… - Toxicology and applied …, 2013 - Elsevier
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor which plays a
role in the development of multiple tissues and is activated by a large number of ligands, …

Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct interactions with basal transcription …

JC Rowlands, IJ Mcewan, JA Gustafsson - Molecular pharmacology, 1996 - ASPET
The aryl hydrocarbon (or dioxin) receptor (AhR) is a ligand-activated basic helix-loop-helix (bHLH)
protein that heterodimerizes with the bHLH protein AhR nuclear translocator (ARNT) …

Adverse outcome pathways: from research to regulation scientific workshop report

…, M Embry, J Matheson, JC Rowlands… - Regulatory toxicology …, 2016 - Elsevier
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical
mode of action, starting with a molecular initiating event such as receptor binding, continuing …