Synthesis of 2-deoxy-2, 2-difluoro-D-ribose and 2-deoxy-2, 2'-difluoro-D-ribofuranosyl nucleosides

LW Hertel, JS Kroin, JW Misner… - The Journal of Organic …, 1988 - ACS Publications
6 followed with the synthesis of a series of l-(2-deoxy-2, 2-difluororibofuranosyl) pyrimidines
as part of our program in the design and synthesis of nucleosides of potential value as …

An enantioselective synthesis of cis perhydroisoquinoline LY235959

…, MJ Martinelli, JW Misner… - The Journal of …, 1998 - ACS Publications
A novel synthesis of NMDA receptor antagonist LY235959 (1) has been achieved in 13%
overall yield and 17 steps from (R)-pantolactone (7). Highlights of the synthesis include (a) use …

Enantioselective syntheses of 1-carbacephalosporins from chemoenzymically derived β-hydroxy-α-amino acids: applications to the total synthesis of carbacephem …

BG Jackson, SW Pedersen, JW Fisher, JW Misner… - Tetrahedron, 2000 - Elsevier
Serine hydroxymethyltransferase (SHMT) derived from recombinant E. coli was found to be
able to catalyze the condensation between glycine and 4-pentenaldehyde, affording …

Enantioselective synthesis of the carbacephem antibiotic loracarbef via Mitsunobu and Dieckmann cyclization from an unnatural amino acid

JW Misner, JW Fisher, JP Gardner, SW Pedersen… - Tetrahedron letters, 2003 - Elsevier
The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient
and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which …

Synthesis and biological activity of trans-2, 3-dihydroraloxifene

CR Schmid, AL Glasebrook, JW Misner… - Bioorganic & medicinal …, 1999 - Elsevier
The synthesis and biological evaluation of trans-2,3-dihydroraloxifene, 2, is described. The
synthesis proceeds in 8 steps in 20% overall yield. Relative trans 2,3-stereochemistry is …

[PDF][PDF] Preclinical studies on LY237733, a potent and selective serotonergic antagonist.

…, DL Nelson, DO Calligaro, KD Kurz, JW Misner… - … of Pharmacology and …, 1992 - Citeseer
8B-N-cyclohexyl-6-methyl-1-(1-methylethyl) ergoline-8-carboxamide (LY237733) is an
ergoline with potent and highly selective 5-hydroxytryptamine(5-HI) antagonist activity. The in …

[PDF][PDF] A singularity-free empty universe

CW Misner, AH Taub - Sov. Phys. JETP, 1969 - jetp.ras.ru
A solution of the empty space Einstein equations R JW= 0 is studied. It is a cosmological
model in the sense that it incorporates a metric which has closed homogeneous space-like …

Classical physics as geometry

CW Misner, JA Wheeler - Annals of physics, 1957 - Elsevier
If classical physics be regarded as comprising gravitation, source free electromagnetism,
unquantized charge, and unquantized mass of concentrations of electromagnetic field energy (…

Integration of a highly selective demethylation of a quaternized ergoline into a one-pot synthesis of pergolide

JW Misner, JH Kennedy, WS Biggs - Organic Process Research & …, 1997 - ACS Publications
We have developed a high-yielding one-pot synthesis of pergolide (10) from dihydrolysergol
(1), which was isolated as pergolide mesylate (6, Permax), a semisynthetic ergot alkaloid …

(8. beta.)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity

JW Misner, WL Garbrecht, G Marzoni… - Journal of medicinal …, 1990 - ACS Publications
A series of (8/3)-6-methylergoline amide derivatives was synthesized with various alkyl
substituents in the^-position in order to evaluate their effectiveness in blocking vascular 5HT2 …