Synthesis of 2-deoxy-2, 2-difluoro-D-ribose and 2-deoxy-2, 2'-difluoro-D-ribofuranosyl nucleosides
LW Hertel, JS Kroin, JW Misner… - The Journal of Organic …, 1988 - ACS Publications
6 followed with the synthesis of a series of l-(2-deoxy-2, 2-difluororibofuranosyl) pyrimidines
as part of our program in the design and synthesis of nucleosides of potential value as …
as part of our program in the design and synthesis of nucleosides of potential value as …
An enantioselective synthesis of cis perhydroisoquinoline LY235959
…, MJ Martinelli, JW Misner… - The Journal of …, 1998 - ACS Publications
A novel synthesis of NMDA receptor antagonist LY235959 (1) has been achieved in 13%
overall yield and 17 steps from (R)-pantolactone (7). Highlights of the synthesis include (a) use …
overall yield and 17 steps from (R)-pantolactone (7). Highlights of the synthesis include (a) use …
Enantioselective syntheses of 1-carbacephalosporins from chemoenzymically derived β-hydroxy-α-amino acids: applications to the total synthesis of carbacephem …
BG Jackson, SW Pedersen, JW Fisher, JW Misner… - Tetrahedron, 2000 - Elsevier
Serine hydroxymethyltransferase (SHMT) derived from recombinant E. coli was found to be
able to catalyze the condensation between glycine and 4-pentenaldehyde, affording …
able to catalyze the condensation between glycine and 4-pentenaldehyde, affording …
Enantioselective synthesis of the carbacephem antibiotic loracarbef via Mitsunobu and Dieckmann cyclization from an unnatural amino acid
JW Misner, JW Fisher, JP Gardner, SW Pedersen… - Tetrahedron letters, 2003 - Elsevier
The nucleus of the carbacephem antibiotic loracarbef was synthesized in a highly efficient
and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which …
and enantioselective fashion from 2S,3S-2-amino-3-hydroxy-6-heptenoic acid (AHHA), which …
Synthesis and biological activity of trans-2, 3-dihydroraloxifene
CR Schmid, AL Glasebrook, JW Misner… - Bioorganic & medicinal …, 1999 - Elsevier
The synthesis and biological evaluation of trans-2,3-dihydroraloxifene, 2, is described. The
synthesis proceeds in 8 steps in 20% overall yield. Relative trans 2,3-stereochemistry is …
synthesis proceeds in 8 steps in 20% overall yield. Relative trans 2,3-stereochemistry is …
[PDF][PDF] Preclinical studies on LY237733, a potent and selective serotonergic antagonist.
…, DL Nelson, DO Calligaro, KD Kurz, JW Misner… - … of Pharmacology and …, 1992 - Citeseer
8B-N-cyclohexyl-6-methyl-1-(1-methylethyl) ergoline-8-carboxamide (LY237733) is an
ergoline with potent and highly selective 5-hydroxytryptamine(5-HI) antagonist activity. The in …
ergoline with potent and highly selective 5-hydroxytryptamine(5-HI) antagonist activity. The in …
[PDF][PDF] A singularity-free empty universe
CW Misner, AH Taub - Sov. Phys. JETP, 1969 - jetp.ras.ru
A solution of the empty space Einstein equations R JW= 0 is studied. It is a cosmological
model in the sense that it incorporates a metric which has closed homogeneous space-like …
model in the sense that it incorporates a metric which has closed homogeneous space-like …
Classical physics as geometry
CW Misner, JA Wheeler - Annals of physics, 1957 - Elsevier
If classical physics be regarded as comprising gravitation, source free electromagnetism,
unquantized charge, and unquantized mass of concentrations of electromagnetic field energy (…
unquantized charge, and unquantized mass of concentrations of electromagnetic field energy (…
Integration of a highly selective demethylation of a quaternized ergoline into a one-pot synthesis of pergolide
JW Misner, JH Kennedy, WS Biggs - Organic Process Research & …, 1997 - ACS Publications
We have developed a high-yielding one-pot synthesis of pergolide (10) from dihydrolysergol
(1), which was isolated as pergolide mesylate (6, Permax), a semisynthetic ergot alkaloid …
(1), which was isolated as pergolide mesylate (6, Permax), a semisynthetic ergot alkaloid …
(8. beta.)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity
JW Misner, WL Garbrecht, G Marzoni… - Journal of medicinal …, 1990 - ACS Publications
A series of (8/3)-6-methylergoline amide derivatives was synthesized with various alkyl
substituents in the^-position in order to evaluate their effectiveness in blocking vascular 5HT2 …
substituents in the^-position in order to evaluate their effectiveness in blocking vascular 5HT2 …