A series of substituted 2-(aminopyridyl)- and 2-(aminopyrimidinyl)thiazole-5-carboxamides
was identified as potent Src/Abl kinase inhibitors with excellent antiproliferative activity …

Substituted N-(4-(2-aminopyridin-4-yloxy)-3-fluoro-phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamides
were identified as potent and selective Met kinase inhibitors. …

N-Acyl-2-aminothiazoles with nonaromatic acyl side chains containing a basic amine were
found to be potent, selective inhibitors of CDK2/cycE which exhibit antitumor activity in mice. …

Self-focusing effects in large, high power laser amplifiers become manifest as small-scale
beam instabilities and as large-scale phase aberrations. Spatial filtering has been shown to …

For cancer cells to survive and proliferate, they must escape normal immune destruction. One
mechanism by which this is accomplished is through immune suppression effected by up-…

High throughput screening identified 2-acetamido-thiazolylthio acetic ester 1 as an inhibitor
of cyclin-dependent kinase 2 (CDK2). Because this compound is inactive in cells and …

Certain damage observed on the optics in NOVA is consistent with a phenomenon akin to
holographic imaging. (NOVA is the Lawrence Livermore National Laboratory’s 10-beam Nd:…

Continuing structure−activity studies were performed on the 2,3,4,5-tetrahydro-1-(imidazol-4-ylalkyl)-1,4-benzodiazepine
farnesyltransferase (FT) inhibitors. These studies demonstrated …

A series of substituted 4-(4-fluoro-1H-indol-5-yloxy)pyrrolo[2,1-f][1,2,4]triazine-based
inhibitors of vascular endothelial growth factor receptor-2 kinase is reported. Structure−activity …

Conformationally constrained 2-pyridone analogue 2 is a potent Met kinase inhibitor with an
IC 50 value of 1.8 nM. Further SAR of the 2-pyridone based inhibitors of Met kinase led to …