Conventional antidepressants require 2–8 weeks for a full clinical response. In contrast, two
rapidly acting antidepressant interventions, low-dose ketamine and sleep deprivation (SD) …

Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent, …

The heterogeneity of neural gene expression and the spatially limited expression of many
low-abundance messenger RNAs in the brain has made cloning and analysis of such …

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

In mammalian tissues the C-terminal amide structure has been found to occur only in
neuroactive or hormonally-active peptides 1 . About half known neuropeptide and peptide …

Hypothesized that perceived coping self-efficacy mediates the effects of environmental events
on catecholamine secretion. Differential levels of perceived self-efficacy were induced in …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns.
However, to date, there is no direct evidence of circadian clock dysregulation in the brains …

THE isolation and identification of endogenous opiate-like peptides from mammalian brain 1,2
, and from pituitary 3–5 has led to an active investigation of their pharmacological …