Bioavailability and pharmacokinetics of magnesium after administration of magnesium salts to humans

VV Ranade, JC Somberg - American journal of therapeutics, 2001 - journals.lww.com
Therapeutically, magnesium salts represent an important class of compounds and exhibit
various pharmacologic actions. Examples of magnesium salts are ionic magnesium and …

Pharmacology and pharmacokinetics of amiodarone.

MD Freedman, JC Somberg - Journal of clinical pharmacology, 1991 - europepmc.org
Amiodarone is a unique antiarrhythmic agent originally developed as a vasodilator.
Classified electrophysiologically as a Type III antiarrhythmic, it also has both nonspecific …

KCNE1 mutations cause Jervell and Lange-Nielsen syndrome

…, G Assmann, X Qu, JC Somberg… - Nature …, 1997 - pubmed.ncbi.nlm.nih.gov
… E Schulze-Bahr, Q Wang, H Wedekind, W Haverkamp, Q Chen, Y Sun, C Rubie, M Hördt,
JA Towbin, M Borggrefe, G Assmann, X Qu, JC Somberg, G Breithardt, C Oberti, H Funke …

Usefulness of QT dispersion as an electrocardiographically derived index

JC Somberg, J Molnar - American Journal of Cardiology, 2002 - ajconline.org
Increased heterogeneity of ventricular repolarization favors the development of serious
ventricular arrhythmias. One way to assess increased dispersion of repolarization is the …

Intravenous lidocaine versus intravenous amiodarone (in a new aqueous formulation) for incessant ventricular tachycardia

JC Somberg, SJ Bailin, CI Haffajee… - The American journal of …, 2002 - Elsevier
The effectiveness of intravenous amiodarone for the treatment of incessant (shock resistant)
ventricular tachycardia (VT) has not been established. This study evaluated the efficacy of a …

QT prolongation and the antiarrhythmic efficacy of amiodarone

…, S Lam, D Keefe, DS Miura, JC Somberg - Journal of the American …, 1986 - Elsevier
Amiodarone is an antiarrhythmic agent known to cause prolongation of action potential
duration which is reflected in the electrocardiogram as a prolongation of the QT interval. …

Lack of a hypotensive effect with rapid administration of a new aqueous formulation of intravenous amiodarone

JC Somberg, S Timar, SJ Bailin, F Lakatos… - The American journal of …, 2004 - Elsevier
Hypotension is the most frequent adverse event reported with intravenous amiodarone.
Hypotension has been attributed to the vasoactive solvents of the standard formulation (…

[HTML][HTML] Multicenter trial of sotalol for suppression of frequent, complex ventricular arrhythmias: a double-blind, randomized, placebo-controlled evaluation of two …

…, EM Gilbert, RH Miller, DL Keefe, JC Somberg… - Journal of the American …, 1986 - Elsevier
Sotalol is a unique beta-adrenergic blocking agent with additional actions characteristic of
Vaughn-Williams class III antiarrhythmic agents in experimental models. To test the efficacy of …

Influence of electrolyte abnormalities on interlead variability of ventricular repolarization times in 12-lead electrocardiography

…, J Molnar, V Ranade, JC Somberg - American journal of …, 2001 - journals.lww.com
Increased QT dispersion (QT d) has been associated with increased risk for ventricular
arrhythmias. Pathologic extracellular electrolyte concentrations may result in ventricular …

QT interval dispersion in healthy subjects and survivors of sudden cardiac death: circadian variation in a twenty-four-hour assessment

…, JE Rosenthal, JS Weiss, JC Somberg - The American journal of …, 1997 - Elsevier
Twenty-four-hour acquisition of QT dispersion (QTd) from the Holter and the circadian
variation of QTd were evaluated in 20 survivors of sudden cardiac death (SCD), in 20 healthy …