User profiles for J B Lombardini

John b. Lombardini

Professor of Pharmacology, Texas Tech University Health Sciences Center
Verified email at ttuhsc.edu
Cited by 3860

Treatment of hypertension with oral taurine: experimental and clinical studies

JD Militante, JB Lombardini - Amino acids, 2002 - Springer
Oral taurine treatment has been studied extensively as a hypotensive agent. Several rat
models of hypertension have been used to prove that dietary taurine supplementation can …

Taurine: retinal function

JB Lombardini - Brain Research Reviews, 1991 - Elsevier
The status and potential functions of taurine in the retina have been reviewed. Taurine is
present in high concentrations in the retina of all species tested, while the retinal concentrations …

Taurine: evidence of physiological function in the retina

JD Militante, JB Lombardini - Nutritional neuroscience, 2002 - Taylor & Francis
Lombardini, JB (1993a) "Partial characterization of an approximately 20 K M, retinal
protein whose phosphorylation is inhibited by taurine", Biochemical Pharmacology 46, 1445-1451…

Interaction between the actions of taurine and angiotensin II

SW Schaffer, JB Lombardini, J Azuma - Amino acids, 2000 - Springer
The amino acid, taurine, is an important nutrient found in very high concentration in excitable
tissue. Cellular depletion of taurine has been linked to developmental defects, retinal …

Cysteine Oxygenase: II. Studies on the Mechanism of the Reaction with 18Oxygen

JB Lombardini, TP Singer, PD Boyer - Journal of Biological Chemistry, 1969 - Elsevier
The mechanism of the conversion of L-cysteine to L-cysteinesulfinic acid in the presence of
oxygen, reduced pyridine nucleotide, Fe 2+ , and an enzyme from rat liver cytoplasm was …

Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction: Deductions concerning the conformation of methionine

JB Lombardini, AW Coulter, P TALALAY - Molecular Pharmacology, 1970 - ASPET
Steric, electronic, and conformational requirements are described for analogues of L-methionine
essential to their function as substrates or inhibitors of the methionine …

Formation, functions and regulatory importance of S-adenosyl-L-methionine

JB Lombardini, P Talalay - Advances in enzyme regulation, 1971 - Elsevier
The present status of knowledge of the synthesis and the metabolic and regulatory functions
of S-adenosyl-l-methionine (AMe) is reviewed. The mechanism of the enzymatic synthesis …

Age-related retinal degeneration in animal models of aging: possible involvement of taurine deficiency and oxidative stress

J Militante, JB Lombardini - Neurochemical research, 2004 - Springer
There is strong evidence that the retina degenerates with age. Electroretinogram deficits and
photoreceptor cell death and structural abnormalities have been observed in both animal …

Dietary taurine supplementation: hypolipidemic and antiatherogenic effects

JD Militante, JB Lombardini - Nutrition Research, 2004 - Elsevier
Taurine supplementation may prove to be a safe and convenient method to reverse high blood
cholesterol and the associated rise in atherosclerosis. Although human studies are limited…

The effect of taurine supplementation on patients with type 2 diabetes mellitus

KB Chauncey, TE Tenner, JB Lombardini… - Taurine 5: Beginning the …, 2003 - Springer
Diabetes Mellitus (DM) is the fifth leading cause of death in the US. Nearly 80% of diabetic
mortality is secondary to cardiovascular disease resulting from atherosclerosis. Current …