Cognitive‐performance recovery of Alzheimer's disease model mice by modulation of early soluble amyloidal assemblies

A Frydman‐Marom, M Rechter, I Shefler… - Angewandte …, 2009 - Wiley Online Library
Alzheimer s disease (AD), a neurodegenerative disorder for which there is no disease-modifying
therapy, is the foremost cause of dementia in elderly people.[1] An initial hypothesis …

T cell-induced mast cell activation: a role for microparticles released from activated T cells

I Shefler, P Salamon, T Reshef, A Mor… - The Journal of …, 2010 - journals.aai.org
Close physical proximity between mast cells and T cells has been demonstrated in several T
cell-mediated inflammatory processes. However, the way by which mast cells are activated …

T cell–derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases

I Shefler, M Pasmanik-Chor, D Kidron… - Journal of allergy and …, 2014 - Elsevier
Background It has recently been shown that microvesicles derived from activated T cells can
stimulate human mast cells (MCs) to degranulate and release several cytokines. Objective …

Microvesicles derived from normal and multiple myeloma bone marrow mesenchymal stem cells differentially modulate myeloma cells' phenotype and translation …

…, S Tartakover Matalon, I Shefler… - …, 2017 - academic.oup.com
Multiple myeloma (MM) cells’ interaction with the bone marrow (BM) microenvironment
critically hinders disease therapy. Previously, we showed that MM co-culture with BM-…

Lung cancer-derived extracellular vesicles: a possible mediator of mast cell activation in the tumor microenvironment

P Salamon, YA Mekori, I Shefler - Cancer Immunology, Immunotherapy, 2020 - Springer
Activated mast cells are often found in the tumor microenvironment. They have both pro- and
anti-tumorigenic roles, depending on the tumor type. Several lines of evidence suggest that …

[HTML][HTML] Extracellular vesicles as emerging players in intercellular communication: relevance in mast cell-mediated pathophysiology

I Shefler, P Salamon, YA Mekori - International journal of molecular …, 2021 - mdpi.com
Mast cells are major effector cells in eliciting allergic responses. They also play a significant
role in establishing innate and adaptive immune responses, as well as in modulating tumor …

MicroRNA-4443 regulates mast cell activation by T cell–derived microvesicles

I Shefler, P Salamon, F Levi-Schaffer, A Mor… - Journal of Allergy and …, 2018 - Elsevier
Background The mechanism by which mast cells (MCs) are activated in T cell–mediated
inflammatory processes remains elusive. Recently, we have shown that microvesicles derived …

Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase β regulate IgE receptor-triggered exocytosis in cultured mast cells

Y Kapp-Barnea, S Melnikov, I Shefler… - The Journal of …, 2003 - journals.aai.org
We examined the possible occurrence and function of neuronal Ca 2+ sensor 1 (NCS-1/frequenin)
in the mast cell line rat basophilic leukemia, RBL-2H3. This protein has been …

[HTML][HTML] MicroRNA involvement in allergic and non-allergic mast cell activation

I Shefler, P Salamon, YA Mekori - International Journal of Molecular …, 2019 - mdpi.com
Allergic inflammation is accompanied by the coordinated expression of numerous genes
and proteins that initiate, sustain, and propagate immune responses and tissue remodeling. …

[HTML][HTML] Tumor-derived extracellular vesicles induce CCL18 production by mast cells: a possible link to angiogenesis

I Shefler, P Salamon, T Zitman-Gal, YA Mekori - Cells, 2022 - mdpi.com
Mast cells (MCs) function as a component of the tumor microenvironment (TME) and have
both pro- and anti-tumorigenic roles depending on the tumor type and its developmental stage…