Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
Y Fujimori, K Katsuno, I Nakashima… - … of Pharmacology and …, 2008 - ASPET
The low-affinity sodium glucose cotransporter (SGLT2) plays an important role in renal
glucose reabsorption and is a remarkable transporter as a molecular target for the treatment of …
glucose reabsorption and is a remarkable transporter as a molecular target for the treatment of …
Mutated GM‐CSF‐based CAR‐T cells targeting CD116/CD131 complexes exhibit enhanced anti‐tumor effects against acute myeloid leukaemia
…, Y Inada, H Morokawa, I Nakashima… - Clinical & …, 2021 - Wiley Online Library
Objectives As the prognosis of relapsed/refractory (R/R) acute myeloid leukaemia (AML)
remains poor, novel treatment strategies are urgently needed. Clinical trials have shown that …
remains poor, novel treatment strategies are urgently needed. Clinical trials have shown that …
Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty rats
Y Fujimori, K Katsuno, K Ojima, I Nakashima… - European journal of …, 2009 - Elsevier
The low-affinity sodium glucose cotransporter (SGLT2) is responsible for most of the glucose
reabsorption in the kidney and has been highlighted as a novel therapeutic target for the …
reabsorption in the kidney and has been highlighted as a novel therapeutic target for the …
Non-viral inducible caspase 9 mRNA delivery using lipid nanoparticles against breast cancer: An in vitro study
I Nakashima, S Saito, E Akahoshi, S Yagyu… - Biochemical and …, 2022 - Elsevier
Breast cancer is a complex heterogeneous disease with unique molecular subtypes, which
limits the development of optimized treatment strategies for each subtype. Cancer gene …
limits the development of optimized treatment strategies for each subtype. Cancer gene …
[HTML][HTML] Mutated GM-CSF-Based CAR T-cells targeting CD116/CD131 complexes exhibit enhanced anti-tumor effects against acute myeloid leukemia
…, M Nagai, Y Inada, H Morokawa, I Nakashima… - Blood, 2020 - Elsevier
Background: The prognosis of relapsed/refractory (R/R) acute myeloid leukemia (AML)
remains poor; therefore, novel treatment strategies are required urgently. Meanwhile, recent …
remains poor; therefore, novel treatment strategies are required urgently. Meanwhile, recent …
[HTML][HTML] Tumor-tropic liposome-mediated therapeutic delivery of mRNA for T cell malignancies
S Saito, I Nakashima, A Hasegawa, E Akahoshi… - Blood, 2020 - Elsevier
Introduction: Treatment options for relapsed T cell leukemia are limited, and the prognosis
remains dismal. Therefore, the development of new therapies is crucial. A liposomal delivery …
remains dismal. Therefore, the development of new therapies is crucial. A liposomal delivery …
[PDF][PDF] Contribution of prostaglandin transporter OATP2A1/SLCO2A1 to placenta-to-maternal hormone signaling and labor induction
…, M Tachikawa, K Hosoya, I Tamai, E Nakashima… - Iscience, 2020 - cell.com
We evaluated the contribution of organic anion transporting polypeptide 2A1 (OATP2A1/SLCO2A1),
a high-affinity carrier for prostaglandins (PGs), to the parturition process. At …
a high-affinity carrier for prostaglandins (PGs), to the parturition process. At …
Kinetic analysis and characterization of the bacterial regrowth after treatment of Escherichia coli with β-lactam antibiotics
…, A Tsujix, T Asano, I Tamai, E Nakashima… - Journal of …, 1984 - Elsevier
The generation curves of Escherichia coli B/r and E. coli NIHJ JC-2 in the presence of
several β-lactam antibiotics were studied from the kinetic point of view. Apparent first-order …
several β-lactam antibiotics were studied from the kinetic point of view. Apparent first-order …
Phenolic Derivatives with Anti‐Acetylcholinesterase Inhibitory Activities from Galeola nudifolia in Vietnam
KM Do, Y Nakashima, T Kodama, YE Lee… - Chemistry & …, 2023 - Wiley Online Library
A new phenolic derivative, galeomalate A (1), together with five known structurally related
compounds (2‐6), was isolated from the ethyl acetate extract of Galeola nudifolia collected in …
compounds (2‐6), was isolated from the ethyl acetate extract of Galeola nudifolia collected in …
Arginase inhibitory activities of guaiane sesquiterpenoids from Curcuma comosa rhizomes
NN Hoang, T Kodama, Y Nakashima, KM Do… - Journal of Natural …, 2023 - Springer
Arginases are bimanganese enzymes involved in many human illnesses, and thus are targets
for disease treatments. The screening of traditional medicinal plants demonstrated that an …
for disease treatments. The screening of traditional medicinal plants demonstrated that an …