Cannabis: pharmacology and toxicology in animals and humans

IB Adams, BR Martin - Addiction, 1996 - Wiley Online Library
Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ 9 ‐tetrahydrocannabinol (δ 9 ‐THC), produces a myriad of …

Assessment of anandamide interaction with the cannabinoid brain receptor: SR 141716A antagonism studies in mice and autoradiographic analysis of receptor …

IB Adams, DR Compton, BR Martin - Journal of Pharmacology and …, 1998 - ASPET
Anandamide is the newly discovered endogenous cannabinoid ligand that binds to brain
cannabinoid receptors and shares most, but not all, of the pharmacological properties of Δ 9 -…

Evaluation of cannabinoid receptor binding and in vivo activities for anandamide analogs.

IB Adams, W Ryan, M Singer, BF Thomas… - … of Pharmacology and …, 1995 - ASPET
Recent evidence implicates anandamide as the endogenous ligand for the cannabinoid
receptor. One purpose of this study was to determine the structural requirements for …

Structure− activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore

BF Thomas, IB Adams, SW Mascarella… - Journal of medicinal …, 1996 - ACS Publications
Anandamides are endogenous fatty acid ethanolamides that have been shown to bind to
the cannabinoid receptor and possess cannabimimetic activity yet are structurally dissimilar …

Pharmacological and behavioral evaluation of alkylated anandamide analogs

IB Adams, W Ryan, M Singer, RK Razdan… - Life sciences, 1995 - Elsevier
Anandamide (arachidonylethanolamide), isolated from porcine brain, has been shown to
bind to the cannabinoid receptor and also to produce cannabimimetic activity in …

Phase Ib trial of atezolizumab in combination with nab-paclitaxel in patients with metastatic triple-negative breast cancer (mTNBC).

S Adams, JR Diamond, EP Hamilton, PR Pohlmann… - 2016 - ascopubs.org
1009 Background: Atezolizumab (atezo; MPDL3280A) is a humanized MAb that inhibits
binding of PD-L1 to PD-1 and B7.1, thus restoring tumor-specific T-cell immunity. Atezo has …

An open-label phase Ib dose-escalation study of TRC105 (anti-endoglin antibody) with bevacizumab in patients with advanced cancer

…, BK Seon, WD Figg, CJ Peer, D Alvarez, BJ Adams… - Clinical cancer …, 2014 - AACR
Purpose: Endoglin, an endothelial cell membrane receptor expressed on angiogenic tumor
vessels, is essential for angiogenesis and upregulated in the setting of VEGF inhibition. …

[PDF][PDF] The Civil War Letters of James Rush Holmes

IB Adams - Western Pennsylvania History: 1918-2022, 1961 - journals.psu.edu
… of Marcellin C Adams, a great-nephew of Rush Holmes. "Janev >" Miss Sarah Jane Adams,
Adams, long-time valued member of this Society, the Daughters of the American Revolution …

Glycoprotein Ib‐mediated platelet activation: A signalling pathway triggered by thrombin

F Adam, MC Guillin… - European Journal of …, 2003 - Wiley Online Library
Platelet activation by thrombin plays a major role in the development of haemostasis and
thrombosis. Thrombin activates human platelets by cleaving the N‐terminal region of G‐protein…

Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain …

S Hurvitz, R Singh, B Adams… - … in medical oncology, 2018 - journals.sagepub.com
Background: Improving outcomes for patients with human epidermal growth factor 2-positive
(HER2+) central nervous system (CNS) metastases remains an unmet clinical need. This …