The RAS/RAF signaling pathway is an important mediator of tumor cell proliferation and
angiogenesis. The novel bi-aryl urea BAY 43-9006 is a potent inhibitor of Raf-1, a member of the …

Background: HER-2/neu, which encodes a receptor tyrosine kinase, is amplified and
overexpressed in 20%–25% of human breast cancers. Such tumors are often resistant to hormone …

Bruton's tyrosine kinase (Btk) is a therapeutic target for rheumatoid arthritis, but the cellular
and molecular mechanisms by which Btk mediates inflammation are poorly understood. Here …

Objective To investigate the relationship among near-work activity, night-lights, and myopia
in schoolchildren in Singapore and Xiamen, China. Methods The refractive error and ocular …

Cherng RJ, Liu CF, Lau TW, Hong RB: Effect of treadmill training with body weight support
on gait and gross motor function in children with spastic cerebral palsy. Am J Phys Med …

Purpose: To examine the prevalence of myopia in rural and urban schoolchildren in Xiamen,
China, and to assess the impact of environmental factors on rates of myopia. Methods: …

Spleen tyrosine kinase (Syk) is an attractive drug target in autoimmune, inflammatory, and
oncology disease indications. The most advanced Syk inhibitor, R406, 1 (or its prodrug form …

Breath analysis provides a way to diagnose diseases by detection of special odors in breaths;
one of its clinical applications, electronic nose, has been proved as a non-invasive and …

To protect outsourced data in cloud storage against corruptions, adding fault tolerance to
cloud storage together with data integrity checking and failure reparation becomes critical. …

Experiments were conducted to investigate the effects of melting temperature and the presence
of internal fins on the performance of a phase change material (PCM)-based heat sink …