CD38 is a 42-kilodalton glycoprotein expressed extensively on B and T lymphocytes. CD38
exhibits a structural homology to Aplysia adenosine diphosphate (ADP)-ribosyl cyclase. This …

ADP-ribosyl cyclase catalyzes the cyclization of NAD + + to produce cyclic ADP-ribose (cADPR),
which is emerging as an endogenous regulator of the Ca 2+ 2+ -induced Ca 2+ 2+ …

Calcium-induced calcium release (CICR) may function widely in calcium-mediated cell
signaling, but has been most thoroughly characterized in muscle cells. In a homogenate of sea …

We have previously shown that alkaline treatment of NADP generates a derivative which can
mobilize Ca from sea urchin egg homogenates (Clapper, DL, Walseth, TF, Dargie, PJ, and …

Incubation of NAD + with extracts from sea urchin eggs resulted in production of a metabolite
which could mobilize intracellular Ca 2+ stores of the eggs. In this study we present …

Cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP)
are two Ca 2+ messengers derived from NAD and NADP, respectively. Although NAADP is a …

Abscisic acid (ABA) is the primary hormone that mediates plant responses to stresses such
as cold, drought, and salinity. Single-cell microinjection experiments in tomato were used to …

Cells possess various mechanisms for transducing external signals to intracellular responses.
The discovery of inositol 1,4,5-trisphosphate (IP3) as a messenger for mobilizing internal …

Cyclic ADP-ribose (cADPR) is a metabolite of NAD+ that is as active as inositol trisphosphate
(IP3) in mobilizing intracellular Ca2+ in sea urchin eggs. The activity of the enzyme …

Cyclic ADP-ribose (cADPR) is a naturally-occurring metabolite of NAD + that is as effective
as inositol trisphosphate in mobilizing intracellular Ca 2+ . A series of analogs modified at the …