Social isolation rearing‐induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion‐related behaviors in juvenile …

…, K Tsuritani, Y Kuwahara, H Kamei… - Journal of …, 2008 - Wiley Online Library
Experiences during brain development may influence the pathogenesis of developmental
disorders. Thus, social isolation (SI) rearing after weaning is a useful animal model for …

Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the …

…, D Ibi, E Someya, H Koike, H Kamei… - Journal of …, 2011 - Soc Neuroscience
Recurrent seizure activity has been shown to induce a variety of permanent structural changes
in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal plasticity, …

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex

T Nagai, K Takuma, H Kamei, Y Ito… - Learning & …, 2007 - learnmem.cshlp.org
Several lines of evidence suggest that extracellular signal-regulated kinase1/2 (ERK1/2)
and dopaminergic system is involved in learning and memory. However, it remains to be …

Neuroactive neurosteroids as endogenous effectors for the sigma1 (σ1) receptor: pharmacological evidence and therapeutic opportunities

T Maurice, VL Phan, A Urani, H Kamei… - The Japanese Journal …, 1999 - jstage.jst.go.jp
Neuroactive neurosteroids, including progesterone, allopregnanolone, pregnenolone and
dehydroepiandrosterone, represent steroid hormones synthesized de novo in the brain and …

Neonatal polyI: C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood

…, H Koike, A Shiraki, K Takuma, H Kamei… - Neuroscience …, 2009 - Elsevier
It has been reported that viral infection in the first and second trimesters of pregnancy in
humans increases the risk of subsequently developing schizophrenia. To develop a mouse …

Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice

H Kamei, T Nagai, H Nakano, Y Togan… - Biological …, 2006 - Elsevier
BACKGROUND: Recent clinical studies have suggested that chronic use of methamphetamine
(METH) induces long-term cognitive deficits. To clarify the mechanism of METH-induced …

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

T Nagai, R Murai, K Matsui, H Kamei, Y Noda… - …, 2009 - Springer
Rationale Cognitive deficits, including memory impairment, are regarded as a core feature
of schizophrenia. Aripiprazole, an atypical antipsychotic drug, has been shown to improve …

[HTML][HTML] Involvement of pallidotegmental neurons in methamphetamine-and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice …

…, D Ibi, T Nagai, K Takahashi, H Kamei… - …, 2008 - nature.com
We have previously demonstrated that pallidotegmental GABAergic neurons play a crucial
role in prepulse inhibition (PPI) of the startle reflex in mice through the activation of GABA B …

Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol

…, M Dohniwa, D Ibi, H Mizoguchi, H Kamei… - …, 2007 - Springer
Rationale Although chronic use of methamphetamine (METH) leads to long-lasting cognitive
dysfunction in humans, there are few reports about an animal model that reflects METH-…

Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: imbalance of prefrontal serotonergic and dopaminergic …

Y Noda, H Kamei, T Mamiya, H Furukawa… - …, 2000 - Elsevier
Repeated treatment with phencyclidine (PCP) prolonged the immobility time in a forced
swimming test, compared with saline treatment, this behavioral change being regarded as …