The great flexibility offered by transformation optics for controlling electromagnetic radiation
by virtually re-shaping the electromagnetic space has inspired a myriad of dream-tailored …

Phosphodiesterase (PDE) enzymes are responsible for the inactiviation of cyclic adenosine
monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Phosphodiesterase …

In the last decade, a technique termed transformation optics has been developed for the
design of novel electromagnetic devices. This method defines the exact modification of …

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as
rheumatoid arthritis (RA), by specific targeting of the JAK1 pathway. Examination of the preferred …

Melanin-concentrating hormone (MCH) has been known to be an appetite-stimulating peptide
for a number of years. However, it is only recently that MCH has been discovered to be the …

Addition of the 4-fluorophenylpyrazole group to the previously described 2-azadecalin
glucocorticoid receptor (GR) antagonist 1 resulted in significantly enhanced functional activity. …

… Buckley , Natasha Davies , Hazel J. Dyke † , Elizabeth J. Frost , Philip J. Gilbert , Duncan
R. … Davies, HJ Dyke, PJ Gilbert, DR Hannah, AF Haughan, CA Hunt, WR Pitt, RH Profit …

The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors
of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro …

2, 5-Dialkylated benzoquinoneshave been prepared from 4-alkenyl-4-hydroxycyclobutenones
by thermolysis followed by oxidation, while 2, 6-dialkylated benzoquinones are available …

… Author links open overlay panel Matthew J Barnes , Nicola Cooper , Richard J Davenport
, Hazel J Dyke , Fiona P Galleway , Frances CA Galvin , Lewis Gowers , Alan F Haughan …