Fetal hepatic drug elimination

JA Ring, H Ghabrial, MS Ching, RA Smallwood… - Pharmacology & …, 1999 - Elsevier
The majority of studies of fetal hepatic elimination have concentrated on the expression and
activity of the metabolizing enzymes, but the unique physiologic milieu of the fetal liver …

Neonatal hepatic drug elimination

PJ Gow, H Ghabrial, RA Smallwood… - Pharmacology & …, 2001 - Wiley Online Library
After the transition from in utero to newborn life, the neonate becomes solely reliant upon its
own drug clearance processes to metabolise xenobiotics. Whilst most studies of neonatal …

[HTML][HTML] Reduced tubular cation transport in diabetes: prevented by ACE inhibition

…, Z Cao, TM Osicka, LM Russo, G Jerums, H Ghabrial… - Kidney international, 2003 - Elsevier
Reduced tubular cation transport in diabetes: Prevented by ACE inhibition. Background The
renal clearance of organic cations is important for the homeostasis of a number of …

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites

MS Ching, CL Blake, H Ghabrial, SW Ellis… - Biochemical …, 1995 - Elsevier
The inhibitory effects of dihydroquinidine, quinidine and several quinidine metabolites on
cytochrome P450 2D6 (CYP2D6) activity were examined. CYP2D6 heterologously expressed …

Differential bidirectional transfer of indinavir in the isolated perfused human placenta

S Sudhakaran, H Ghabrial, RL Nation… - Antimicrobial agents …, 2005 - Am Soc Microbiol
The protease inhibitor (PI) indinavir may be used in the management of human immunodeficiency
virus (HIV) infection during pregnancy. Poor maternal-to-fetal transfer of indinavir has …

Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans

JHM Schellens, H Ghabrial… - Clinical …, 1991 - Wiley Online Library
The effects of quinidine on oxidative routes of drug metabolism mediated by different forms
of cytochrome P450 were investigated in 10 healthy subjects. Each subject was studied on …

Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2

VS Haritos, MS Ching, H Ghabrial… - Pharmacogenetics …, 1998 - journals.lww.com
Dexfenfluramine has been widely used as an appetite suppressant in the treatment of
obesity. It was recently shown that the apparent non-renal clearance of dexfenfluramine was …

Propranolol hydroxylation and N-desisopropylation by cytochrome P4502D6: studies using the yeast-expressed enzyme and NADPH/O2 and cumene hydroperoxide …

N Bichara, MS Ching, CL Blake, H Ghabrial… - Drug metabolism and …, 1996 - ASPET
We have studied the enantioselectivity and regioselectivity of ring-hydroxylation and N-desisopropylation
of R(+)- and S(-)-propranolol in microsomes from yeast expressing cytochrome …

Hepatic Kupffer cell phagocytotic function in rats with erythrocytic‐stage malaria

MS Nobes, H Ghabrial, KM Simms… - Journal of …, 2002 - Wiley Online Library
Background: In the erythrocytic phase of malaria, Kupffer cells show marked hypertrophy and
hyperplasia and are filled with malarial pigment. However, phagocytic function in this state …

Determinants of placental drug transfer: studies in the isolated perfused human placenta

M Bassily, H Ghabrial, RA Smallwood… - Journal of …, 1995 - Wiley Online Library
There is little information on the effects of maternal and fetal placental blood flow rates,
which can change independently, on the placental transfer rate of drugs of different placental …