Alpha-2 adrenergic receptor development in rat CNS: an autoradiographic study

HK Happe, CL Coulter, ME Gerety, JD Sanders… - Neuroscience, 2004 - Elsevier
During development norepinephrine plays a role in determining the morphologic organization
of the CNS and the density and future responsiveness of adrenergic receptors. α-2 …

Postnatal development of the dopamine transporter: a quantitative autoradiographic study

CL Coulter, HK Happe, LC Murrin - Developmental Brain Research, 1996 - Elsevier
The dopamine transporter performs an important role in regulatinf neurochemical transmission
at dopaminergic synapses, as well as dopamine synthetic activity in dopaminergic …

Cholinergic receptors: dual roles in transduction and plasticity

BJ Morley, HK Happe - Hearing research, 2000 - Elsevier
The regional distributions and possible functions of nicotinic acetylcholine receptors (nAChRs)
in the developing and adult auditory rat brain are reviewed. The predominant nAChR in …

Juvenile rats in the forced-swim test model the human response to antidepressant treatment for pediatric depression

AL Reed, HK Happe, F Petty, DB Bylund - Psychopharmacology, 2008 - Springer
Rationale Currently, there are limited treatment options for major depressive disorder in children
and adolescents compared to the options available for adults. Many effective treatments …

Development of the norepinephrine transporter in the rat CNS

JD Sanders, HK Happe, DB Bylund, LC Murrin - Neuroscience, 2005 - Elsevier
The norepinephrine transporter (NET) plays a major role in regulating the actions of
norepinephrine by removing norepinephrine from the synapse. Many studies suggest …

Localization and quantification of the dopamine transporter: comparison of [3H] WIN 35,428 and [125I] RTI-55

CL Coulter, HK Happe, DA Bergman, LC Murrin - Brain research, 1995 - Elsevier
Transport into the presynaptic terminal by the dopamine transporter is the primary mechanism
for removing dopamine from the synaptic cleft. This transporter is a specific marker for …

In situ hybridization analysis of CHOT1, a creatine transporter, in the rat central nervous system

HK Happe, LC Murrin - Journal of Comparative Neurology, 1995 - Wiley Online Library
A putative choline transporter (CHOT1) has been cloned from rat brain and is reported to
express a high‐affinity, sodium‐dependent, hemicholinium‐3‐insensitive choline transporter in …

High‐Affinity Choline Transport Sites: Use of [3H]Hemicholinium‐3 as a Quantitative Marker

HK Happe, LC Murrin - Journal of neurochemistry, 1993 - Wiley Online Library
… Drug treatments have been shown to regulate ['H]HC3 binding site density in neonatal
animals to the same extent as found in the adult (Happe and Murrin, 19926). This suggests that …

Gene expression profiling in the hippocampus of learned helpless and nonhelpless rats

R Kohen, S Kirov, GP Navaja, HK Happe… - The …, 2005 - nature.com
In the learned helplessness (LH) animal model of depression, failure to attempt escape from
avoidable environmental stress, LH, indicates behavioral despair, whereas nonhelpless (NH…

Distribution and postnatal development of α7 nicotinic acetylcholine receptors in the rodent lower auditory brainstem

HK Happe, BJ Morley - Developmental brain research, 2004 - Elsevier
The distribution and quantity of the α7 nicotinic acetylcholine receptor (nAChR) were mapped
in the nuclei of the superior olivary complex, lateral lemniscus, and inferior colliculus in the …