A number of widely different animal seizure models have been employed in the search for
new and novel anticonvulsant drugs useful for the tratment of human epilepsy. At present, no …

Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular
those with haematological malignancies undergoing remission-induction chemotherapy for …

Cancer patients frequently require central venous catheters for therapy and parenteral nutrition
and are at high risk of central venous catheter–related infections (CRIs). Moreover, CRIs …

Originally described as a model of ‘psychomotor seizures’ (J. Pharmacol. Exp. Ther. (1953)
107–273), the 6 Hz corneal stimulation model was abandoned shortly after its description …

The anticonvulsant topiramate is effective in laboratory animals against maximal electroshock
seizures, amygdala kindling, and spike-wave discharges and has demonstrated efficacy in …

… White HS, Brown D, Skeen GA, Wolf HH, Twyman RE. The anticonvulsant topiramate
displays a unique ability to potentiate GABA-evoked chloride currents. Epilepsia 1995;36(suppl3):…

Ganaxolone (CCD 1042) is a 3β-methyl-substituted analog of the endogenous neuroactive
steroid 3α-hydroxy-5α-pregnan-20-one. Ganaxolone inhibited binding of the γ-aminobutyric …

The anticonvulsant activity of the novel drug D-23129 (N-(2-amino-4-(4-fluorobenzylamino)phenyl)carbamic
acid ethyl ester) was evaluated in animal models of epileptic seizures. D-…

The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and
Oncology (DGHO) here presents its updated recommendations for the treatment of …

There is no widely accepted standard for antifungal prophylaxis in patients with hematologic
malignancies. The Infectious Diseases Working Party of the German Society for …