Obesity is closely associated with the metabolic syndrome, a combination of disorders
including insulin resistance, diabetes, dyslipidemia, and hypertension. A role for local …

… Furthermore, there was no obvious difference in the amounts of cell surface HA-epitope
in HEK 293 cells between 48 h and 49 h after cDNA transfection (data not shown). Thus, …

There is increasing evidence that the conversion of big endothelin-1 (big ET-1) to endothelin-1
(ET-1) is specifically inhibited by the metalloproteinase inhibitor phosphoramidon. We …

… produced (2) in the presence of catalytic amount of H 2 SO 4 in quinoline (Scheme 1). After
… -t-BuOH] to convert the carboxyl group to amino (CO 2 H→CON 3 →NCO→NHCO 2 Bu t …

… the curve of vehicle and the curve of drugs at 2-11 h after dosing. Trough is expressed as
the difference between both curves at 24 h after dosing. The trough per peak (T/P) expresses …

It is suggested that endothelin-1 (ET-1), a potent vasoconstrictor peptide, is involved in the
pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). We …

… U protein V (mg/kgl24 h) … moderate; 4‘ marked; 11 values calculated by H-test followed
by U-testi a) Number of animals, h) Comparison with saline-treated animals fed normal diet (U—…

… Urine was collected for two consecutive 1-h periods. … /h iv for 2 h, respectively, with ilv infusion
of TP; and group 5 receiving AT III 300 U/kg followed by infusion of 75 U/kg/h iv for 2 h with …

… The amounts of renin released in the first, the second and the third periods were 9.8 + 0.3,
9.5 + 0.4 and 9.5 + 0.2 ng AI/h per mg wet tissue, respectively. The first period was taken as …

To test for evidence of stroke-preventive action, we initially examined the effect on salt-loaded
stroke-prone spontaneously hypertensive rats of chronic treatment with 4-(4-benzhy-…