[HTML][HTML] Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase

MH Park, HK Jin, J Bae - Experimental & molecular medicine, 2020 - nature.com
Aging, which is associated with age-related changes in physiological processes, is the most
significant risk factor for the development and progression of neurodegenerative diseases, …

Intracerebral transplantation of bone marrow-derived mesenchymal stem cells reduces amyloid-beta deposition and rescues memory deficits in Alzheimer's disease …

JK Lee, HK Jin, S Endo, EH Schuchman, JE Carter… - Stem …, 2010 - academic.oup.com
Alzheimer's disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) and the
formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal …

[HTML][HTML] Sphingolipids in neuroinflammation: A potential target for diagnosis and therapy

JY Lee, HK Jin, J Bae - BMB reports, 2020 - ncbi.nlm.nih.gov
Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as
signaling molecules for regulating a diverse range of cellular processes, including cell …

Polymorphisms and the differential antiviral activity of the chicken Mx gene

JH Ko, HK Jin, A Asano, A Takada, A Ninomiya… - Genome …, 2002 - genome.cshlp.org
The nucleotide sequence of chicken Mx cDNA was reported earlier using the White Leghorn
breed in Germany, but it showed no enhanced resistance to viruses. In this study, the …

Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through …

…, W Oh, YS Yang, JG Suh, BH Lee, HK Jin… - Neurobiology of …, 2012 - Elsevier
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSC) have a potential
therapeutic role in the treatment of neurological disorders, but their current clinical usage …

Bone marrow-derived mesenchymal stem cells reduce brain amyloid-β deposition and accelerate the activation of microglia in an acutely induced Alzheimer's disease …

JK Lee, HK Jin, J Bae - Neuroscience letters, 2009 - Elsevier
The therapeutic potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) has
recently been explored in various pathological conditions of the central nervous system (CNS…

Bone marrow-derived mesenchymal stem cells promote neuronal networks with functional synaptic transmission after transplantation into mice with …

…, JE Carter, M Modo, EH Schuchman, HK Jin - Stem …, 2007 - academic.oup.com
Recent studies have shown that bone marrow-derived MSCs (BM-MSCs) improve neurological
deficits when transplanted into animal models of neurological disorders. However, the …

Stromal vascular fraction from adipose tissue forms profound vascular network through the dynamic reassembly of blood endothelial cells

YJ Koh, BI Koh, H Kim, HJ Joo, HK Jin… - … , and vascular biology, 2011 - Am Heart Assoc
Objective— Tremendous efforts have been made to establish effective therapeutic
neovascularization using adipose tissue-derived stromal vascular fraction (SVF), but the efficiency is …

The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease

…, H Lee, J Shin, JE Carter, T Sakamoto, HK Jin… - Neuroscience …, 2010 - Elsevier
The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of
extracellular amyloid-β peptide (Aβ) in the form of amyloid plaques in the brain parenchyma and …

Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease

JK Lee, HK Jin, MH Park, B Kim, PH Lee… - Journal of Experimental …, 2014 - rupress.org
… JK Lee and HK Jin contributed equally to this paper. … He performed experiments and analyzed
data, JK Lee, HK Jin, and JS Bae designed the study and wrote the paper. EH Schuchman …