Central cholinergic factors may play a role in the ætiology of affective disorders. Specifically,
a given affective state may represent a balance between central cholinergic and adrenergic …

Methylphenidate (Ritalin) hydrochloride was administered intravenously to schizophrenic,
manic, and depressed patients during the active phase of their illness and upon recovery and …

Physostigmine, a reversible centrally active acetylcholinesterase inhibitor, was administered
over a short period to eight patients with manic symptoms in a double-blind study. Patients …

The authors describe the antagonistic effects of physostigmine, a centrally acting
acetylcholinesterase inhibitor, and methylphenidate, an amphetamine-like stimulant, on manic and …

Rats were pretreated with methylscopolamine. One group received neostigmine or
physostigmine followed by methylphenidate. Physostigmine, but not neostigmine prevented the …

Three female schizophrenic patients receiving a combination of psychotropic agents, including
the antiparkinsonian agent benztropine mesylate, developed the central anticholinergic …

IPA COPYRIGHT: ASHP Six hospitalized psychiatric patients were given chlorpromazine
alone and in combination with a magnesium trisilicate, aluminum hydroxide gel-type antacid. …

The biochemical effects of d- and lp-chloroamphetamine (PCA) were compared with the brain
levels of the unchanged drug at various times after a single injection. Initially both isomers …

A collaborative program to modify the Draize irritancy test was conducted at eight industrial
laboratories to study (1) the effects of treating rabbit eyes with a topical anesthetic prior to …

To the Editor.— Duvoisin and Katz (206:1963-1965, 1968) indicated that the anticholinergic
drugs, including scopolamine, atropine, and various antiparkinsonian agents, can cause a …