Characteristics and functions of the cardiac swelling-activated Cl current (I Cl,swell ) are
considered in physiologic and pathophysiologic settings. I Cl,swell is broadly distributed …

We have identified a 35 amino acid peptide toxin of the inhibitor cysteine knot family that
blocks cationic stretch-activated ion channels. The toxin, denoted GsMTx-4, was isolated from …

Control of heart rate in critically ill patients who develop atrial fibrillation or atrial flutter can
be difficult. Amiodarone may be an alternative agent for heart rate control if conventional …

Gadolinium (Gd 3+ ) blocks cation-selective stretch-activated ion channels (SACs) and thereby
inhibits a variety of physiological and pathophysiological processes. Gd 3+ sensitivity has …

The clinical utility of ibutilide fumarate (Corvert) for the acute conversion of atrial tachyarrhythmias
to normal sinus rhythm has been demonstrated in several randomized, placebo-…

Objectives : This study evaluated the long-term reliability of an implantable cardioverter
defibrillator (ICD) lead to determine the incidence, clinical presentation, and management of lead …

Introduction: Atrial arrhythmias often complicate congestive heart failure (CHF). We characterized
inducible atrial tachyarrhythmias and electrophysiologic alterations in dogs with CHF …

The hypothesis that cellular hypertrophy in congestive heart failure (CHF) modulates
mechanosensitive (ie, swelling- or stretch-activated) anion channels was tested. Digital video …

Adenosine has a negative dromotropic effect and modulates hypoxia-induced atrioventricular
(AV) conduction delay. To further characterize the negative dromotropic effect of …

… Human specimens were taken from explanted end-stage failing hearts (HF) or healthy donor
hearts not suitable for transplantation (NF). A canine model of coronary microembolizations …