The predominant expression of phosphoinositide 3-kinase δ (PI3Kδ) in leukocytes and its
critical role in B and T cell functions led to the hypothesis that selective inhibitors of this isoform …

We have synthesized iodinated resiniferatoxin bearing a 4-hydroxy-5-iodo-3-methoxyphenylacetate
ester (I-RTX) and have characterized its activity on rat and human TRPV1 (VR1) …

Inhibition of the lipid kinase PI3Kδ is a promising principle to treat B and T cell driven inflammatory
diseases. Using a scaffold deconstruction–reconstruction strategy, we identified 4-aryl …

In this study, we describe the rapid identification of potent binders for the WD40 repeat
domain (WDR) of DCAF1. This was achieved by two rounds of iterative focused screening of a …

Selective G‐quadruplex ligands offer great promise for the development of anti‐cancer
therapies. A novel series of divalent cationic naphthalene diimide ligands that selectively bind to …

The synthesis and biological evaluation of a series of 2-aryl indoles with high affinity for the
human neurokinin-1 (hNK1) receptor are reported, concentrating on optimisation of the …

… Author links open overlay panel Kevin Dinnell a , Gary G Chicchi d , Madhumeeta J Dhar
c , Jason M Elliott a , Gregory J Hollingworth a , Marc M Kurtz d , Mark P Ridgill a , Wayne …

Background Tissue mast cell numbers are dynamically regulated by recruitment of
progenitors from the vasculature. It is unclear whether progenitors are recruited during allergic …

… Hollingworth, Gemma Perkins and Joseph Sweeney *,t … J 16 15 … Coupling constants (J)
are quoted in Hz. Reactions involving chemicals or intermediates sensitive to air and/or …

Naphthalene diimide (NDI) is a central scaffold that has been commonly used in the design
of G-quadruplex (G4) ligands. Previous work revealed notable anticancer activity of a …