T cells must be activated before they can elicit damage to allografts, through interaction of
their T cell receptor (TCR) with peptide-MHC complex and through accessory molecules. …

The activities of proteases in the lung, specifically matrix metalloproteinases (MMPs), have
been implicated in driving the inflammation and lung destruction observed in smokers with …

OX40 is a member of the TNFR superfamily that has potent costimulatory properties.
Although the impact of blockade of the OX40–OX40 ligand (OX40L) pathway has been well …

Background. OX40 is a member of the tumor necrosis factor receptor superfamily and is a
potent T-cell costimulatory molecule. Although the impact of blockade of the OX40-OX40L …

Background Candidate compounds being developed to treat chronic obstructive pulmonary
disease are typically assessed using either acute or chronic mouse smoking models; …

The objective of this research is to examine, first, whether iso-strain, a combination of high
psychological demands, low decision latitude and low social support in remote workers …

Transplantation is the treatment of choice for end stage organ failure however current
immunosuppressive therapies whilst effective at preventing acute allograft rejection, fail to prevent …

The activities of proteases in the lung, specifically matrix metalloproteinases (MMPs), have
been implicated in driving the inflammation and lung destruction observed in smokers with …

Objectives The objectives of this study are to explore stroke patients’ and carers’ beliefs and
concerns about medicines and identify the barriers to medication adherence for secondary …