Genetic alteration of phospholipase C β3 expression modulates behavioral and cellular responses to μ opioids

W Xie, GM Samoriski, JP McLaughlin… - Proceedings of the …, 1999 - National Acad Sciences
Morphine and other μ opioids regulate a number of intracellular signaling pathways, including
the one mediated by phospholipase C (PLC). By studying PLC β3-deficient mice, we have …

[HTML][HTML] Evidence that a protein‐protein interaction 'hot spot'on heterotrimeric G protein βγ subunits is used for recognition of a subclass of effectors

…, SF Huang, BP Gangadhar, GM Samoriski… - The EMBO …, 2001 - embopress.org
To understand the requirements for binding to G protein βγ subunits, phage‐displayed random
peptide libraries were screened using immobilized biotinylated βγ as the target. Selected …

Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain

SR Chen, G Samoriski, HL Pan - Neuropharmacology, 2009 - Elsevier
Diabetic neuropathic pain remains an unmet clinical problem and is poorly relieved by
conventional analgesics. N-methyl-d-aspartate (NMDA) receptors play an important role in central …

Repeated generalized seizures induce time-dependent changes in the behavioral seizure response independent of continued seizure induction

GM Samoriski, CD Applegate - Journal of Neuroscience, 1997 - Soc Neuroscience
This study examined both the acute and long-lasting changes in seizure susceptibility that
occur in response to the repeated induction of generalized seizure activity. Daily flurothyl-…

Effects of valproate, phenytoin, and MK‐801 in a novel model of epileptogenesis

CD Applegate, GM Samoriski, K Özduman - Epilepsia, 1997 - Wiley Online Library
Purpose: We have developed and characterized a novel model of epileptogenesis based
on the convulsive actions of flurothyl in mice. The hallmark feature of this model is a reliable …

Differential spatial patterns of Fos induction following generalized clonic and generalized tonic seizures

GM Samoriski, DT Piekut, CD Applegate - Experimental neurology, 1997 - Elsevier
The expression of generalized clonic and generalized tonic seizures has been suggested to
result from the activation of different and independent neuronal circuits. Using the induction …

Evidence for the interaction of brainstem systems mediating seizure expression in kindling and electroconvulsive shock seizure models

CD Applegate, GM Samoriski, JL Burchfiel - Epilepsy research, 1991 - Elsevier
Amygdala kindling was observed to increase significantly the proportion of rats that exhibited
tonic hindlimb extension in response to corneal electroshock stimulation. Mechanical …

Enhancement of antidepressant-like effects but not brain-derived neurotrophic factor mRNA expression by the novel N-methyl-D-aspartate receptor antagonist …

T Kos, B Legutko, W Danysz, G Samoriski… - Journal of Pharmacology …, 2006 - ASPET
Improved efficacy in the treatment of depression may be achieved by the combined use of
several antidepressants. In the present study, acute administration of the novel N-methyl-d-…

Comments on “memantine blocks α7* nicotinic acetylcholine receptors more potently than N-methyl-d-aspartate receptors in rat hippocampal neurons”

P Banerjee, G Samoriski, S Gupta - Journal of Pharmacology and …, 2005 - ASPET
The following is a response to the report by Aracava et al.(2005) entitled “Memantine Blocks
α7* Nicotinic Acetylcholine Receptors More Potently Than N-Methyl-D-aspartate Receptors …

Functional compartmentalization of opioid desensitization in primary sensory neurons

GM Samoriski, RA Gross - Journal of Pharmacology and Experimental …, 2000 - ASPET
The cellular correlates of desensitization or tolerance are poorly understood. To address this,
we studied acute and long-term μ-opioid desensitization, with respect to Ca 2+ currents, in …