Structural basis for gluten intolerance in celiac sprue

L Shan, Ų Molberg, I Parrot, F Hausch, F Filiz, GM Gray… - Science, 2002 - science.org
Celiac Sprue, a widely prevalent autoimmune disease of the small intestine, is induced in
genetically susceptible individuals by exposure to dietary gluten. A 33-mer peptide was …

Intestinal digestive resistance of immunodominant gliadin peptides

…, L Shan, NA Santiago, GM Gray… - American Journal of …, 2002 - journals.physiology.org
Two recently identified immunodominant epitopes from α-gliadin account for most of the
stimulatory activity of dietary gluten on intestinal and peripheral T lymphocytes in patients with …

Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue

…, H Arentz-Hansen, Ų Molberg, GM Gray… - Journal of proteome …, 2005 - ACS Publications
Dietary gluten proteins from wheat, rye, and barley are the primary triggers for the immuno-pathogenesis
of Celiac Sprue, a widespread immune disease of the small intestine. Recent …

Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue

L Shan, T Marti, LM Sollid, GM Gray… - Biochemical …, 2004 - portlandpress.com
Prolyl endopeptidases have potential for treating coeliac sprue, a disease of the intestine
caused by proteolytically resistant peptides from proline-rich prolamins of wheat, barley and rye…

Carbohydrate digestion and absorption: Role of the small intestine

GM Gray - New England Journal of Medicine, 1975 - Mass Medical Soc
DIETARY carbohydrate accounts for about half the calories ingested by man and consists of
the polysaccharides, starch and glycogen, and the disaccharides, sucrose and lactose. In …

Starch digestion and absorption in nonruminants

GM Gray - The Journal of nutrition, 1992 - Elsevier
Starch digestion and absorption is augmented appreciably by physical processing of grain
or legume and by heating to 100C for several minutes before its ingestion. Starch, a …

[PDF][PDF] Rational design of combination enzyme therapy for celiac sprue

…, J Ehren, J Xia, A Johannsen, TB Stuge, GM Gray… - Chemistry & biology, 2006 - cell.com
Celiac sprue (also known as celiac disease) is an inheritable, gluten-induced enteropathy
of the upper small intestine with an estimated prevalence of 0.5%–1% in most parts of the …

[HTML][HTML] A food-grade enzyme preparation with modest gluten detoxification properties

J Ehren, B Moron, E Martin, MT Bethune, GM Gray… - PloS one, 2009 - journals.plos.org
Background and Aims Celiac sprue is a life-long disease characterized by an intestinal
inflammatory response to dietary gluten. A gluten-free diet is an effective treatment for most …

Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization

T Marti, Ų Molberg, Q Li, GM Gray, C Khosla… - Journal of Pharmacology …, 2005 - ASPET
Celiac Sprue is a widely prevalent immune disease of the small intestine induced by dietary
gluten intake in genetically susceptible individuals. It has been suggested that prolyl …

Intestinal diffusion barrier: unstirred water layer or membrane surface mucous coat?

KW Smithson, DB Millar, LR Jacobs, GM Gray - Science, 1981 - science.org
The dimensions of the small intestinal diffusion barrier interposed between luminal nutrients
and their membrane receptors were determined from kinetic analysis of substrate hydrolysis …