Catalytic antibodies that hydrolyze (−)-cocaine obtained by a high-throughput procedure

JR Cashman, CE Berkman, GE Underiner - Journal of Pharmacology and …, 2000 - ASPET
Antibodies to a 2β-carboxamido-2β-phosphonate transition-state analog of (−)-cocaine
benzoate ester hydrolysis were elicited in mice. A large number of hybridoma cell lines were …

Multifaceted consequences of holding two [8] annulene rings face-to-face. Synthesis, structural characteristics, and reduction behavior of [22](1, 5) …

…, MA Kesselmayer, GE Underiner… - Journal of the …, 1992 - ACS Publications
The doubly-decked [8] annulene 11 has been prepared in 13 steps from the known diketone
15. The scheme takes advantage of the aramia ting capacity of the Cook-Weiss reaction …

Silaamidide Salts: Synthesis, structure, and reactions

GE Underiner, RP Tan, DR Powell… - Journal of the American …, 1991 - ACS Publications
Five silaamidides have been prepared and characterized: lithium AVV-bis (2, 4, 6-tri-/er/-butylphenyl)
phenylsilaamidide (2), lithium NJ9'-bis (2, 4, 6-tri-rert-butylphenyl) …

Stereoselective inhibition of human butyrylcholinesterase by pbosphonotbiolate analogs of (+)-and (−)-cocaine

CE Berkman, GE Underiner, JR Cashman - Biochemical pharmacology, 1997 - Elsevier
The hydrolysis of cocaine (benzoylecgonine methyl ester) to ecgonine methyl ester by human
butyrylcholinesterase (BuChE; EC 3.1.1.8) has been shown previously to constitute an …

CT-2576, an inhibitor of phospholipid signaling, suppresses constitutive and induced expression of human immunodeficiency virus.

…, C Tompkins, GE Underiner… - Proceedings of the …, 1995 - National Acad Sciences
Viruses such as human immunodeficiency virus (HIV) require cellular activation for
expression. Cellular activation in lymphoid cells is associated with augmented accumulation of …

Synthesis of the First Silaamidide

GE Underiner, R West - Angewandte Chemie International …, 1990 - Wiley Online Library
The ether-free silaamidide salt 3 exhibits a 29Si NMR resonance at 6= 7, shifted strongly
downfield from the resonance for 1 (6=-29). 2 and 4 have 29Si NMR chemical shifts of 6= 3 and …

Abnormal Weiss-Cook condensation of cis-6-cyclodecene-1, 2-dione with dimethyl 1, 3-acetonedicarboxylate. The consequences of ring strain release

LA Paquette, GE Underiner… - The Journal of Organic …, 1992 - ACS Publications
Notes J. Org. Chem., Vol. 57, No. 12, 1992 3513 under comparably acidic conditions. 9 By
contrast, stirring 6 with dimethyl 1, 3-acetonedicarboxylate (2) in aqueous methanol at pH 8.3 …

Development of a large-scale synthetic route to manufacture (−)-Huperzine A

…, L He, CH Behrens, G Underiner… - … Process Research & …, 2012 - ACS Publications
A safe, practical and scalable process for manufacture of (−)-huperzine A has been developed
and scaled up to manufacture several hundred grams of (−)-huperzine A with chemical …

[CITATION][C] Synthesis of an immunogenic template for the generation of catalytic antibodies for (−)-cocaine hydrolysis

CE Berkman, GE Underiner… - The Journal of Organic …, 1996 - ACS Publications
Abuse of (-)-cocaine has become a major public health problem in the United States. The
relative risk to individuals and the cost to society is difficult to estimate but the burden to the …

Cocaine benzoyl thioester: Synthesis, kinetics of base hydrolysis, and application to the assay of cocaine esterases

JR Cashman, CE Berkman, G Underiner… - Chemical research in …, 1998 - ACS Publications
The synthesis and characterization of diastereomers of cocaine benzoyl thioester is
described. Allococaine benzoyl thioester and allopseudococaine benzoyl thioester were …