Pharmacophore/receptor models for three recombinant GABA A /BzR subtypes (α1β3γ2,
α5β3γ2, and α6β3γ2) have been established via an SAR ligand-mapping approach. This study …

The word" response" in scientific discussions of behavioral activities means simply an
identified behavioral activity. While the responses studied experimen tally are usually …

Increased incidence of osteoporosis in Down syndrome has been reported, but etiology is
not established. We report low bone turnover markers and bone mineral density (BMD) in a …

… Our colleague from the University of Arkansas, Galen Wenger, presented data obtained in
both pigeons and squirrel monkeys with a little-used variation on the DMTS theme in which …

Pathological changes in the central nervous system in two strains of mice (BALB/c and
C57BL/6) and two strains of rats (Long Evans and Sprague Dawley) as a result of trimethyltin (…

Trisomy 21 affects virtually every organ system and results in the complex clinical presentation
of Down syndrome (DS). Patterns of differences are now being recognized as patients’ …

WENGER, GALEN R. AND PB DEWS: The effects of phencyclidine, ketamine, d-amphetamine
and pentobarbital on schedule-controlled behavior in the mouse. J. Pharmacol. Exp. Ther. …

A single injection of reserpine (1 mg kg ip) produced an increased susceptibility to minimal
electroshock seizures, as well as a decrease in whole brain levels of norepinephrine (NE), …

BALB/c mice were injected IP with a single dose of trimethyltin chloride (3.0 mg TMT/kg body
weight). Severe body tremor was observed within 12 hours post-injection. All animals were …

… All drug concentrations were made so that the desired dose could be given in a volume of
1 ml/100 grams of body weight. All doses are expressed as p. moles of free base/kilogram of …