Translation and protein synthesis: macrolides

L Katz, GW Ashley - Chemical reviews, 2005 - ACS Publications
The term “macrolide” was originally proposed by RB Woodward in 1957 as an abbreviation
of macrolactone glycoside antibiotics, a class of natural products composed of macrocyclic …

Classification of large-scale subaqueous bedforms; a new look at an old problem

GM Ashley - Journal of Sedimentary Research, 1990 - pubs.geoscienceworld.org
… The symposium was convened by GM Ashley and RD Kreisa and sponsored by the SEPM
Bedforrns and Bedding Structures Research Group. Most of the ideas presented herein …

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel “unnatural” natural products

…, H Fu, M Betlach, M Betlach, G Ashley - Proceedings of the …, 1999 - National Acad Sciences
The structures of complex polyketide natural products, such as erythromycin, are programmed
by multifunctional polyketide synthases (PKSs) that contain modular arrangements of …

Processes, bar morphology, and sedimentary structures on braided outwash fans, northeastern Gulf of Alaska

JC Boothroyd, GM Ashley - 1975 - archives.datapages.com
The Scott and Yana outwash fans on the northeastern Gulf of Alaska exhibit a succession of
facies from glacier terminus to tidewater that are each characterized by differences of …

Hydrogel drug delivery system with predictable and tunable drug release and degradation rates

GW Ashley, J Henise, R Reid… - Proceedings of the …, 2013 - National Acad Sciences
Many drugs and drug candidates are suboptimal because of short duration of action. For
example, peptides and proteins often have serum half-lives of only minutes to hours. One …

Long-term stabilization of maleimide–thiol conjugates

…, R Reid, L Robinson, GW Ashley… - Bioconjugate …, 2015 - ACS Publications
Michael-addition of a thiol to a maleimide is commonly used for bioconjugation of drugs to
macromolecules. Indeed, both current FDA-approved antibody–drug conjugates…

A model of structure and catalysis for ketoreductase domains in modular polyketide synthases

R Reid, M Piagentini, E Rodriguez, G Ashley… - Biochemistry, 2003 - ACS Publications
A putative catalytic triad consisting of tyrosine, serine, and lysine residues was identified in
the ketoreductase (KR) domains of modular polyketide synthases (PKSs) based on homology …

Late Pliocene Homo and Hominid Land Use from Western Olduvai Gorge, Tanzania

…, RL Hay, CC Swisher, IG Stanistreet, GM Ashley… - Science, 2003 - science.org
Excavation in the previously little-explored western portion of Olduvai Gorge indicates that
hominid land use of the eastern paleobasin extended at least episodically to the west. Finds …

Rhythmic sedimentation in glacial lake Hitchcock, Massachusetts-Connecticut

GM Ashley - 1975 - archives.datapages.com
… Stream water would enter the lake and flolv at a level determined l~g the positive or negative
difference 11et\\~ee11 stream density and lake density. "lnterflo\v" is the term t~setl to describe …

Deposition of climbing‐ripple beds: a flume simulation

GM Ashley, JB Southard, JONC BooTHRoyD - Sedimentology, 1982 - Wiley Online Library
Thirteen runs were made in a small recirculating flume to simulate the deposition of the
climbing‐ripple sequences commonly present in fine‐grained facies of fluvial and deltaic deposits…