The aims of this report are firstly to raise awareness among kineticists and pharmacologists
as to why pharmacokinetic–pharmacodynamic (PKPD) integration is essential for target …

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a
new model for safety pharmacology. So far, a thorough description of their basic …

Objective: The aim was to study factors contributing to torsade de pointes in the acquired long
QT syndrome. Methods: Anaesthetised rabbits or cats were given a continuous infusion of …

Cardiotoxicity is among the leading reasons for drug attrition and is therefore a core subject
in non-clinical and clinical safety testing of new drugs. European Centre for the Validation of …

In the present study the electrophysiological characteristics and the proarrhythmic potential
of cisapride and a structurally related drug, mosapride, were compared. In the anesthetized …

To improve proarrhythmic predictability of preclinical models, we assessed whether human
ventricular-like embryonic stem cell-derived cardiomyocytes (hESC-CMs) can be selected …

INTRODUCTION: Accumulating evidence suggest that drug-induced QT prolongation per
se poorly predicts repolarisation-related proarrhythmia liability. We examined whether beat-by-…

When low doses of clofilium were administered to conscious rabbits, ventricular tachyarrhythmia
(VT) with features typical of torsades de pointes developed. This arrhythmia was further …

AZD7009 (tert-Butyl-2-(7-[(2S)-3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]non-3-yl)ethylcarbamate)
is an antiarrhythmic agent that increases atrial refractoriness…

Introduction: AZD7009 is a novel anti‐arrhythmic compound under development for short‐
and long‐term management of atrial fibrillation and flutter. Electrophysiological studies in …