A method is described for the simultaneous determination of the carboxylic acid and N‐acetyl‐derivatives
of primaquine, in plasma and urine. After oral administration of 45 mg …

Pharmacodynamic and pharmacokinetic studies of omeprazole, a new gastric antisecretory
agent, were undertaken in 8 healthy subjects. The drug was administered orally as an …

The available evidence suggests that for most drugs, adverse effects in the fetus may vary
with gestational state and among species due to: 1. (i) changes in the fetal exposure to the …

The pharmacokinetics of primaquine have been examined in five healthy volunteers who
received single oral doses of 15, 30 and 45 mg of the drug, on separate occasions. Each …

We have investigated the pharmacokinetics of primaquine after acute and chronic administration
of the drug to five healthy Thai volunteers. After acute dosage (15 mg po) mean (+/‐ sd) …

1. Little is known about the comparative plasma protein binding of the antimalarial agents
quinine (QN) and its isomer quinidine (QD). We have examined the in vitro binding of QN and …

1 Ranitidine pharmacokinetics were studied in six healthy volunteers. Following an overnight
fast, doses of 20 mg intravenously 20, 40 and 100 mg orally and 100 mg orally with a …

Six patients suffering from status epilepticus were refractory to parenteral treatment with either
diazepam, amobarbital or both, and were given sodium valproate 200 to 800 mg every 6 …

To discriminate between two widely used models of hepatic drug elimination, the venous
equilibrium and sinusoidal models, we examined the effect of altering perfusate protein binding …

To examine whether changes in inhibition of gastric acid secretion occur during chronic
ranitidine therapy, duodenal ulcer patients in remission were studied before and after 9 months …