Conclusion. Collectively, these studies suggest that endothelial dysfunction (1) is not
unique to chemically induced experimental models of IDDM,(2) is found in both conduit and …

… 52 TODD, GL, CULLAN, GE, CULLAN, GM Isoproterenol-induced myocardial necrosis and
membrane permeability alterations in the isolated perfused rabbit heart. Exp Mol Patho133, …

Long-term diabetes mellitus is characterized by impaired endothelium-dependent relaxation.
In contrast, there is limited information on endothelial function in the early stages of the …

… Pieper GM. Acute amelioration of diabetic endothelial dysfunction with a derivative of the
nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiovasc Pharmacol 1997;29:in press. …

Free radical-initiated lipid peroxidation (LP) following intestinal ischemia/reperfusion (I/R) may
disrupt mucosal integrity. It is unknown if inhibition of LP prevents this injury. We analyzed …

Tetrahydrobiopterin is a cofactor for nitric oxide synthase. In low concentrations of this
cofactor, nitric oxide synthase is known to produce less nitric oxide and, correspondingly, …

… Pieper. Regulation of spontaneous EDRF release in diabetic rat aorta … Address for
reprint requests: GM Pieper, Dept. of Pharmacology and … GM Vascular effects of oxygen-derived …

The present experiments were conducted to determine whether endothelium-dependent
relaxation is impaired in chronic (10-12 wk), streptozotocin-induced diabetic rat aortas and to …

Arginine is a precursor amino acid for the synthesis of nitric oxide by nitric oxide synthase. A
defect in arginine supply could regulate nitric oxide-mediated, endothelium-dependent …

Nuclear factor κB (NFκB) plays a pivotal role in early gene responses by promoting messenger
RNA (mRNA) synthesis for various cell-adhesion molecules and inducible nitric oxide …