Mitochondrial dysfunction is a major mechanism whereby drugs can induce liver injury and
other serious side effects such as lactic acidosis and rhabdomyolysis in some patients. By …

Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological
process that cannot yet be recapitulated in a single in vitro model. Current preclinical …

Background The West African outbreak of Ebola virus disease that peaked in 2014 has caused
more than 11,000 deaths. The development of an effective Ebola vaccine is a priority for …

… Homogenates were centrifuged at 10,000 g for 10 min. The pellets were discarded, and
the supernatants were centrifuged at 100,OOOg for 60 min. Aminopyrine N-demethylase was …

Drug-induced liver injury (DILI) is a major cause of late-stage clinical drug attrition, market
withdrawal, black-box warnings, and acute liver failure. Consequently, it has been an area of …

Background Dengue is the most important mosquito-borne viral disease. In the absence of
specific drugs or vaccines, control focuses on suppressing the principal mosquito vector, …

Amiodarone has been shown to produce microvesicular steatosis of the liver in some
recipients. We have determined the effects of amiodarone on the mitochondrial oxidation of fatty …

Drug-induced liver injury (DILI) in humans is difficult to predict using classical in vitro cytotoxicity
screening and regulatory animal studies. This explains why numerous compounds are …

The development of a highly effective vaccine remains a key strategic goal to aid the control
and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-…

The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria. …