… DR; Kamatchi… GL GABAA receptor … BURT AND KAMATCHI …

Although tricyclic antidepressant (TCA) blockade of cardiac Na + channels is appreciated,
actions on neuronal Na + channels are less clear. Therefore, the effects of TCAs (amitriptyline, …

Muscarinic m1 receptors are inhibited by local anaesthetics (LA) at nM concentrations. To
elucidate in more detail the site(s) of LA interaction, we compared these findings with LA …

Background Glutamate transporters play an important role in maintaining extracellular
glutamate homeostasis. The authors studied the effects of volatile anesthetics on one type of …

Muscarinic acetylcholine signalling plays major roles in regulation of consciousness, cognitive
functioning, pain perception and circulatory homeostasis. Halothane has been shown to …

The genes encoding the α 1A , α 1B , α 1C and α 1E subunits of neuronal high voltage-gated
Ca channels (HVGCCs) were separately expressed with β 1B and α 2 /δ subunits in …

Felbamate (FBM, 2‐phenyl‐1,3‐propanediol dicarbamate), a potential antiepileptic drug (AED),
has an unknown mechanism of action. We examined possible interaction of FBM with …

Protein kinase C (PKC) is implicated in the potentiation of Ca v 2.3 currents by acetyl-β-methylcholine
(MCh), a muscarinic M 1 receptor agonist or phorbol-12-myristate, 13-acetate (PMA…

Ca v 2.2 high voltage-gated calcium channels are regulated by phorbol-12-myristae, 13-acetate
(PMA) via Ser/Thr protein kinase C (PKC) phosphorylation sites in the I–II linker and C-…

GABA A receptors link binding of GABA (γ-aminobutyric acid) to inhibitory chloride flux in
the brain. They are the site of action of several important classes of drugs, and have been …