IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As
such, we examined the release of proinflammatory mediators by human macrophages in …

Objective To examine the cellular mechanisms by which the proinflammatory cytokine
interleukin‐17 (IL‐17) induces the synthesis of 92‐kd gelatinase (matrix metalloproteinase 9 [MMP…

Objective To study the therapeutic effectiveness of ML‐3000, a new antiinflammatory drug
that has balanced dual inhibitory activity against 5‐lipoxygenase and cyclooxygenase, on the …

We have evaluated the cardiovascular effects of intracerebroventricular (icv) injections of
neurotensin (NT) in pentobarbital-anesthetized rats. In most animals, the icv injection of NT (5.4…

The objective of the present study was to identify hypothalamic sites that might be implicated
in the effects of neuropeptide Y (NPY) on both body temperature and food intake. For this …

In order to better delineate the profile of central actions of neuropeptide Y (NPY), the effects
of intracerebroventricular administration of several doses (2.5–20 μg) of the peptide on …

Our previous in vivo structure-activity studies suggested that the putative receptors
mediating the effects of NPY and NPY 2–36 on food intake and body temperature are …

Neurobehavioral effects of neurotensin and structural analogues in which tyrosine in position
11 was replaced by either its d-isomer [D-Tyr 11 ]-NT, phenylalanine [Phe 11 ]-NT or D-…

The synthesis of the four regioisomers of monothionated Leu‐enkephalins (Leu‐Enk) from
previously reported protected precursors is described. The Tyr 1 ‐thio analog was obtained …

The purpose of the present study was to examine and compare the profile of neurobehavioral
effects of rat amylin (r-amylin) and rat calcitonin gene-related peptide (rCGRP), two …