Cardiovascular diseases (CVD) are still the most frequent cause of death in Western Europe.
Pathophysiological experiments revealed in the last years that the vascular endothelium, …

Symmetrical dimethylarginine (SDMA) is the structural isomer of the endogenous nitric
oxide synthase (NOS) inhibitor asymmetric dimethylarginine. Whereas the major route of …

Background and Purpose— Preclinical studies have revealed that the endogenous nitric
oxide synthase inhibitor, asymmetric dimethylarginine (ADMA), increases vascular tone in …

The biochemical influence of flavonolignans from the milk thistleSilybum marianum has been
tested on kidney cells of African green monkeys. Two nonmalignant cell lines were selected…

Objectives— Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide
synthase (NOS), and its accumulation has been associated with cardiovascular disease. …

We report here the effect of aspirin on the onset of replicative senescence. Endothelial cells
that were cultured until cumulative population doublings 40 showed clear signs of aging. …

Recombinant human erythropoietin therapy frequently causes hypertension in humans and
animals with chronic renal failure. Asymmetric dimethylarginine (ADMA) is an endogenous …

BACKGROUND: The endothelial nitric oxide synthase (eNOS) inhibitor asymmetric
dimethylarginine (ADMA) is a well-established risk factor for oxidative stress, vascular dysfunction, …

Telmisartan, in addition to blocking angiotensin (Ang) II type 1 receptor (AT 1 R), activates
peroxisome proliferator activated receptor γ (PPARγ) signaling that interferes with nitric oxide (…

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase
and its accumulation has been associated with cardiovascular disease. We aimed to …