Mechanism of Block of hEag1 K+ Channels by Imipramine and Astemizole

…, D Kerschensteiner, F Major… - The Journal of general …, 2004 - rupress.org
Ether à go-go (Eag; K V 10.1) voltage-gated K + channels have been detected in cancer cell
lines of diverse origin and shown to influence their rate of proliferation. The tricyclic …

Approaches targeting Kv10. 1 open a novel window for cancer diagnosis and therapy

LA Pardo, D Gomez-Varela, F Major… - Current medicinal …, 2012 - ingentaconnect.com
KV10.1 has recently become generally accepted as a promising cancer target, as it is
ectopically expressed in the majority of solid tumors. Due to its cell-surface accessibility, KV10.1 …

Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC‐1065 and the duocarmycins

LF Tietze, F Major, I Schuberth… - … A European Journal, 2007 - Wiley Online Library
Novel diastereomerically pure β‐D‐galactosidic prodrugs (+)‐12 a–e of the cytotoxic
antibiotics CC‐1065 and the duocarmycins were prepared for an antibody directed enzyme …

Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy

…, B Krewer, M Müller, F Major… - ChemMedChem …, 2008 - Wiley Online Library
A severe limitation in cancer therapy is the often insufficient differentiation between malign
and benign tissue using known chemotherapeutics. One approach to decrease side effects is …

[HTML][HTML] Stress of nursing students in clinical simulation: a randomized clinical trial

R Boostel, JVC Felix, C Bortolato-Major… - Revista brasileira de …, 2018 - SciELO Brasil
Objective: To evaluate and compare the perception of stressors by nursing students before
and after a high-fidelity clinical simulation or conventional laboratory practice class. Method: …

… -Resistant Coagulase-Negative Staphylococci in the Community: High Homology of SCCmec IVa between Staphylococcus epidermidis and Major Clones of Methicillin …

…, D Lebeaux, P Francois, B Felix… - The Journal of …, 2010 - academic.oup.com
Background. Data on community spread of methicillin-resistant coagulase-negative
staphylococci (MR-CoNS) are scarce. We assessed their potential role as a reservoir of …

[HTML][HTML] Debriefing evaluation in nursing clinical simulation: a cross-sectional study

C Bortolato-Major, MF Mantovani, JVC Felix… - Revista Brasileira de …, 2019 - SciELO Brasil
Objective: Evaluate the contribution of debriefing after clinical simulations for nursing students.
Method: Quantitative study, conducted with 35 nursing students who participated in five …

[HTML][HTML] Tropical rhodolith beds are a major and belittled reef fish habitat

…, LM Neves, CW Hackradt, F Felix-Hackradt… - Scientific reports, 2021 - nature.com
Understanding habitat-level variation in community structure provides an informed basis for
natural resources’ management. Reef fishes are a major component of tropical marine …

[HTML][HTML] Decreasing rates of major lower-extremity amputation in people with diabetes but not in those without: a nationwide study in Belgium

…, J Boly, C Van Hul, K Doggen, I Dumont, P Felix… - Diabetologia, 2018 - Springer
… We further differentiated between major amputation (any amputation above the ankle) and
… ); major LEAs were additionally subdivided into major below-the-knee amputation and major

Imaging of serotonin transporters and its blockade by citalopram in patients with major depression using a novel SPECT ligand [123I]-ADAM

…, H Amthauer, L Luedemann, H Bruhn, R Felix… - Journal of neural …, 2006 - Springer
We studied the midbrain SERT availability in patients with major depression and assessed
the relation of SERT occupancy by citalopram to the treatment response. 21 non-medicated …