User profiles for F P Guengerich

Fred Guengerich

Professor of Biochemistry, Vanderbilt University
Verified email at vanderbilt.edu
Cited by 126504

Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

FP Guengerich - Chemical research in toxicology, 2001 - ACS Publications
Cytochrome P450 (P450) enzymes catalyze a variety of reactions and convert chemicals to
potentially reactive products as well as make compounds less toxic. Most of the P450 …

The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature

…, T Kamataki, DJ Waxman, FP Guengerich… - DNA and cell …, 1993 - liebertpub.com
We provide here a list of 221 P450 genes and 12 putative pseudogenes that have been
characterized as of December 14, 1992. These genes have been described in 31 eukaryotes (…

Cytochrome p450 and chemical toxicology

FP Guengerich - Chemical research in toxicology, 2008 - ACS Publications
The field of cytochrome P450 (P450) research has developed considerably over the past 20
years, and many important papers on the roles of P450s in chemical toxicology have …

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes …

…, H Yamazaki, M Mimura, Y Inui, FP Guengerich - Journal of pharmacology …, 1994 - ASPET
Interindividual variations in the level and activity of cytochrome P-450 enzymes were
investigated in the liver microsomes of 30 Japanese and 30 Caucasian patients. The P-450 …

Chemical mechanisms of catalysis by cytochromes P-450: a unified view

FP Guengerich, TL Macdonald - Accounts of Chemical Research, 1984 - ACS Publications
Cytochromes P-450 are ubiquitous in nature. The levels of these hemoproteins can be
influenced by many chemicals and the enzymes in turn are capable of me-tabolizing many …

Cytochrome P-450 3A4: regulation and role in drug metabolism

FP Guengerich - Annual review of pharmacology and toxicology, 1999 - annualreviews.org
… Another group of ligands is oligopeptides (FP Guengerich, M Delaforge, D Mansuy,
unpublished results). Several tetra- and pentapeptides have affinities in the low micromolar range, …

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

FP Guengerich, DH Kim, M Iwasaki - Chemical research in …, 1991 - ACS Publications
The role of human cytochrome P-450 IIEl (P-450 IIEl) in the oxidation of a number of suspect
carcinogens was examined by using a variety of approaches, including (1) selective …

Reactions and significance of cytochrome P-450 enzymes

FP Guengerich - Journal of Biological Chemistry, 1991 - Elsevier
Cytochrome P-450 enzymes (EC 1.14. 14.1, nonspecific monooxygenase) catalyze the
oxidations of many chemicals (1). The mass of the substrates ranges from that of ethylene (Mr 28) …

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

FP Guengerich, T Shimada - Chemical research in toxicology, 1991 - ACS Publications
The majority of toxic and carcinogenicchemicals do not produce their detrimental biological
effects by themselves, except perhaps in acute doses. In most cases activation to …

Purification and characterization of liver microsomal cytochromes P-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight …

FP Guengerich, GA Dannan, ST Wright, MV Martin… - Biochemistry, 1982 - ACS Publications
… We have modified methods from our laboratory and others [see Guengerich (1977, 1978a)
and Guengerich & Martin (1980)] todevelop techniques that permit the isolation of eight …