… Frank Tortella and colleagues review the CNS pharmacology of dextromethorphan, its
possible involvement with NMDA or o-recevtors, and the potential clinical importance of this old ‘…

… Tortella is the senior research scientist for traumatic brain injury (TBI) and neuroscience
for the US Army's Medical Research and Materiel Command (USAMRMC). He is the acting …

The ubiquitin proteasome system (UPS) is a major cellular protein degradation pathway that
involves the modulation of key proteins controlling inflammation, cell cycle regulation and …

Ischemia-reperfusion brain injury initiates an inflammatory response involving the expression
of adhesion molecules and cytokines, some of which are regulated by the nuclear …

STUDY OBJECTIVE: This study examines whether serum levels of glial fibrillary acidic
protein breakdown products (GFAP-BDP) are elevated in patients with mild and moderate …

We describe here a new strategy for the treatment of stroke, through the inhibition of NAALADase
(N-acetylated-α-linked-acidic dipeptidase), an enzyme responsible for the hydrolysis of …

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been
identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were to …

BACKGROUND: This study compared early serum levels of ubiquitin C-terminal hydrolase (UCH-L1)
from patients with mild and moderate traumatic brain injury (TBI) with uninjured and …

Introduction Authors of several studies have studied biomarkers and computed tomography (CT)
findings in the acute phase after severe traumatic brain injury (TBI). However, the …

In focal cerebral ischemia, peri-infarct depolarizations (PIDs) cause an expansion of core-infarcted
tissue into adjacent penumbral regions of reversible injury and have been shown to …