Temporal patterns of the cerebral inflammatory response in the rat lithium–pilocarpine model of temporal lobe epilepsy

B Voutsinos-Porche, E Koning, H Kaplan… - Neurobiology of …, 2004 - Elsevier
To better understand the role of inflammatory responses in temporal lobe epilepsy, we
characterized Interleukin1-β (IL1-β), Nuclear Factor-κB (NF-κB), and Cyclooxygenase-2 (COX-2) …

Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy

MA Rigoulot, E Koning, A Ferrandon, A Nehlig - Journal of Pharmacology …, 2004 - ASPET
The lithium-pilocarpine model reproduces the main characteristics of human temporal lobe
epilepsy. After status epilepticus (SE), rats exhibit a latent seizure-free phase characterized …

Selective reorganization of GABAergic transmission in neonatal ventral hippocampal-lesioned rats

J François, A Ferrandon, E Koning… - International Journal …, 2009 - academic.oup.com
Post-mortem studies suggested a disturbance of the GABAergic system in schizophrenia.
Neonatal ventral hippocampal-lesioned (NVHL) rats were used as a neurodevelopmental …

Anxiety and locomotion in Genetic Absence Epilepsy Rats from Strasbourg (GAERS): inclusion of Wistar rats as a second control

…, JB Faure, B Cosquer, E Koning… - …, 2014 - Wiley Online Library
Objective The Genetic Absence Epilepsy Rats from Strasbourg ( GAERS) is a genetic model,
derived from Wistar rats by selective breeding. In all previous studies, GAERS were …

Long‐term pregabalin treatment protects basal cortices and delays the occurrence of spontaneous seizures in the lithium‐pilocarpine model in the rat

V André, MA Rigoulot, E Koning, A Ferrandon… - …, 2003 - Wiley Online Library
Purpose: To determine whether a pharmacologic treatment could delay or prevent the
epileptogenesis induced by status epilepticus (SE) through the protection of some brain areas, we …

A comprehensive behavioral evaluation in the lithium–pilocarpine model in rats: effects of carisbamate administration during status epilepticus

…, B Cosquer, A Ferrandon, K Geiger, E Koning… - …, 2013 - Wiley Online Library
Purpose Administration of carisbamate during status epilepticus ( SE ) prevents the occurrence
of motor seizures in the lithium–pilocarpine model and leads in a subpopulation of rats to …

Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium‐pilocarpine model of mesial temporal lobe epilepsy in …

B Linard, A Ferrandon, E Koning, A Nehlig, E Raffo - Epilepsia, 2010 - Wiley Online Library
Purpose: Although the number of antiepileptic drugs (AEDs) is increasing, none displays
neuroprotective or antiepileptogenic properties that could prevent status epilepticus (SE)–…

Attention and executive functions in a rat model of chronic epilepsy

…, B Cosquer, A Ferrandon, K Herbeaux, E Koning… - …, 2014 - Wiley Online Library
Objective Temporal lobe epilepsy is a relatively frequent, invalidating, and often refractory
neurologic disorder. It is associated with cognitive impairments that affect memory and …

Prolonged low‐dose caffeine exposure protects against hippocampal damage but not against the occurrence of epilepsy in the lithium‐pilocarpine model in the rat

MA Rigoulot, C Leroy, E Koning, A Ferrandon… - …, 2003 - Wiley Online Library
Purpose: Acute caffeine exposure has proconvulsant effects and worsens epileptic and
ischemic neuronal damage. Surprisingly, prolonged caffeine exposure decreases the …

The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal …

J François, E Koning, A Ferrandon, A Nehlig - Epilepsy research, 2006 - Elsevier
Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and
spontaneous recurrent seizures (SRS). Neuroprotective and antiepileptogenic effects of …