Fenobam [N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea] is
an atypical anxiolytic agent with unknown molecular target that has previously been …

We have identified two chemical series of compounds acting as selective positive allosteric
modulators (enhancers) of native and recombinant metabotropic glutamate 1 (mGlu1) …

The metabotropic glutamate receptor 5 (mGlu5) is a glutamate-activated class CG protein-coupled
receptor widely expressed in the central nervous system and clinically investigated as …

In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the
germline genome by silencing mobile genetic elements. This defense system acts in germline …

Major depressive disorder (MDD) is a serious public health burden and a leading cause of
disability. Its pharmacotherapy is currently limited to modulators of monoamine …

Small molecule mGluR1 enhancers based on the lead compound (9H-xanthene-9-carbonyl)-carbamic
acid butyl ester derived from random-screening hit diphenylacetyl-carbamic acid …

Negative allosteric modulators (NAMs) of metabotropic glutamate receptor 5 (mGlu5) have
potential for the treatment of psychiatric diseases including depression, fragile X syndrome (…

The activation of T-lymphocytes is dependent upon, and accompanied by, an increase in
voltage-gated K + conductance. Kv1.3, a Shaker family K + channel protein, appears to play an …

… Eric Vieira, a Alfred Binggeli, a Volker Breu, a Daniel Bur{ Walter Fischli, b Rolf Gtiller,
Georges Hirth{ Hans Peter M~rki{ Marcel Mtiller, a Christian Oefner," Michelangelo Scalone …

Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl-
and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H-…