[PDF][PDF] Nomenclature of voltage-gated calcium channels
EA Ertel, KP Campbell, MM Harpold, F Hofmann… - Neuron, 2000 - cell.com
As new Ca2+ channel genes are cloned, it is apparent that these two alphabetical nomenclatures
will overlap at α1L, which may not mediate an L-type Ca2+ current and Voltage-gated …
will overlap at α1L, which may not mediate an L-type Ca2+ current and Voltage-gated …
Discovery and optimization of isoquinoline ethyl ureas as antibacterial agents
…, D Bur, A Chambovey, EA Ertel… - Journal of medicinal …, 2017 - ACS Publications
Our strategy to combat resistant bacteria consisted of targeting the GyrB/ParE ATP-binding
sites located on bacterial DNA gyrase and topoisomerase IV and not utilized by marketed …
sites located on bacterial DNA gyrase and topoisomerase IV and not utilized by marketed …
Discovery and main pharmacological properties of mibefradil (Ro 40-5967), the first selective T-type calcium channel blocker
JP Clozel, EA Ertel, SI Ertel - Journal of hypertension, 1997 - journals.lww.com
Properties of mibefradil Mibefradil is a novel calcium chan-nel antagonist with structural and
pharmacological characteristics clearly distinct from those of classical calcium antagonists. It …
pharmacological characteristics clearly distinct from those of classical calcium antagonists. It …
Discovery of Clinical Candidate ACT-777991, a potent CXCR3 antagonist for antigen-driven and inflammatory pathologies
EA Meyer, P Aanismaa, EA Ertel, E Huhn… - Journal of Medicinal …, 2023 - ACS Publications
The CXCR3 chemokine receptor is a G protein-coupled receptor mainly expressed on
immune cells from the lymphoid lineage, including activated T cells. Binding of its inducible …
immune cells from the lymphoid lineage, including activated T cells. Binding of its inducible …
T-Type Ca2+ Channels and Pharmacological Blockade: Potential Pathophysiological Relevance
SI Ertel, EA Ertel, JP Clozel - Cardiovascular drugs and therapy, 1997 - Springer
Low-voltage–activated T-type Ca 2+ channelsare present in most excitable tissues including
the heart (mainly pacemakercells), smooth muscle, central and peripheral nervous systems, …
the heart (mainly pacemakercells), smooth muscle, central and peripheral nervous systems, …
Discovery of a potent, selective T-type calcium channel blocker as a drug candidate for the treatment of generalized epilepsies
…, C Roch, M Kessler, EA Ertel… - Journal of Medicinal …, 2017 - ACS Publications
We report here the discovery and pharmacological characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide
derivatives as potent, selective, brain-penetrating T-type calcium …
derivatives as potent, selective, brain-penetrating T-type calcium …
Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator
…, VA Warren, BS Thomas, RM Brochu, EA Ertel… - Biochemistry, 2000 - ACS Publications
Nodulisporic acid (NA) is an indole diterpene fungal product with insecticidal activity. NA
activates a glutamate-gated chloride channel (GluCl) in grasshopper neurons and potentiates …
activates a glutamate-gated chloride channel (GluCl) in grasshopper neurons and potentiates …
Synthesis and characterization of tetrahydropyran-based bacterial topoisomerase inhibitors with antibacterial activity against Gram-negative bacteria
…, C Kohl, HH Locher, P Seiler, EA Ertel… - Journal of Medicinal …, 2017 - ACS Publications
There is an urgent unmet medical need for novel antibiotics that are effective against a
broad range of bacterial species, especially multidrug resistant ones. Tetrahydropyran-based …
broad range of bacterial species, especially multidrug resistant ones. Tetrahydropyran-based …
Inhibitory action of mibefradil on calcium signaling and aldosterone synthesis in bovine adrenal glomerulosa cells
MF Rossier, EA Ertel, MB Vallotton… - Journal of Pharmacology …, 1998 - ASPET
Mibefradil is a new cardiovascular drug with peculiar Ca ++ antagonistic properties. The most
remarkable feature of mibefradil is its unique relative selectivity for T type calcium channels…
remarkable feature of mibefradil is its unique relative selectivity for T type calcium channels…
Novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram positive activity and improved safety profile
…, D Ritz, P Seiler, C Kohl, EA Ertel… - Journal of medicinal …, 2015 - ACS Publications
Novel antibacterial drugs that are effective against infections caused by multidrug resistant
pathogens are urgently needed. In a previous report, we have shown that tetrahydropyran-…
pathogens are urgently needed. In a previous report, we have shown that tetrahydropyran-…