Capacitative calcium entry (CCE) describes Ca 2+ influx into cells that replenishes Ca 2+
stores emptied through the action of IP3 and other agents. It is an essential component of …

The function of pancreatic β-cells is the synthesis and release of insulin, the main hormone
involved in blood glucose homeostasis. Estrogen receptors, ERα and ERβ, are important …

Hormonal stimulation of G q -protein coupled receptors triggers Ca 2+ mobilization from
internal stores. This is followed by a Ca 2+ entry through the plasma membrane.Drosophila Trp …

Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal
transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and …

In voltage-dependent ion channels, a voltage sensor region is responsible for channel
activation and an aqueous pore is responsible for ion conduction. These two processes have …

Steady-state and kinetic properties of gating currents of the Shaker K+ channels were studied
in channels expressed in Xenopus oocytes and recorded with the cut-open oocyte voltage …

During the last 2 years, our laboratory has worked on the elucidation of the molecular basis
of capacitative calcium entry (CCE) into cells. Specifically, we tested the hypothesis that CCE …

During pregnancy, the heart develops a reversible physiological hypertrophic growth in
response to mechanical stress and increased cardiac output; however, underlying molecular …

In voltage-dependent ion channels, pore opening is initiated by electrically driven movements
of charged residues, and this movement generates a gating current. To examine structural …

The basic functional unit of the large‐conductance, voltage‐ and Ca 2 + ‐activated K + (MaxiK,
BK, BK Ca ) channel is a tetramer of the pore‐forming α‐subunit (MaxiKα) encoded by a …