Current and future treatments for persistent pulmonary hypertension in the newborn
J Pedersen, ER Hedegaard… - Basic & clinical …, 2018 - Wiley Online Library
Persistent pulmonary hypertension in newborn ( PPHN ) is a serious and possibly fatal
syndrome characterized by sustained foetal elevation of pulmonary vascular resistance at birth. …
syndrome characterized by sustained foetal elevation of pulmonary vascular resistance at birth. …
Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide–induced relaxation of rat mesenteric small arteries
ER Hedegaard, A Gouliaev, AK Winther… - … of Pharmacology and …, 2016 - ASPET
Endogenous hydrogen sulfide (H 2 S) is involved in the regulation of vascular tone. We
hypothesized that the lowering of calcium and opening of potassium (K) channels as well as …
hypothesized that the lowering of calcium and opening of potassium (K) channels as well as …
Ivabradine: current and future treatment of heart failure
…, D Grimm, ER Hedegaard - Basic & clinical …, 2017 - Wiley Online Library
In heart failure ( HF ), the heart cannot pump blood efficiently and is therefore unable to meet
the body's demands of oxygen, and/or there is increased end‐diastolic pressure. Current …
the body's demands of oxygen, and/or there is increased end‐diastolic pressure. Current …
Inhibition of KV7 channels protects the rat heart against myocardial ischemia and reperfusion injury
ER Hedegaard, J Johnsen, JA Povlsen… - … of Pharmacology and …, 2016 - ASPET
The voltage-gated K V 7 (KCNQ) potassium channels are activated by ischemia and
involved in hypoxic vasodilatation. We investigated the effect of K V 7 channel modulation on …
involved in hypoxic vasodilatation. We investigated the effect of K V 7 channel modulation on …
[HTML][HTML] Non-endothelial endothelin counteracts hypoxic vasodilation in porcine large coronary arteries
Background The systemic vascular response to hypoxia is vasodilation. However, reports
suggest that the potent vasoconstrictor endothelin-1 (ET-1) is released from the vasculature …
suggest that the potent vasoconstrictor endothelin-1 (ET-1) is released from the vasculature …
[HTML][HTML] Small and intermediate calcium-activated potassium channel openers improve rat endothelial and erectile function
…, I Carvacho, ER Hedegaard… - Frontiers in …, 2017 - frontiersin.org
Modulation of endothelial calcium-activated potassium (K Ca ) channels has been proposed
as an approach to restore endothelial function. The present study investigated whether …
as an approach to restore endothelial function. The present study investigated whether …
[HTML][HTML] Associations of plasma nitrite, L-arginine and asymmetric dimethylarginine with morbidity and mortality in patients with necrotizing soft tissue infections
…, AM Wahl, A Perner, MB Madsen, ER Hedegaard… - Shock, 2018 - journals.lww.com
Background: The nitric oxide system could play an important role in the pathophysiology
related to necrotizing soft tissue infection (NSTI). Accordingly, we investigated the association …
related to necrotizing soft tissue infection (NSTI). Accordingly, we investigated the association …
Involvement of hydrogen sulfide in perivascular and hypoxia-induced inhibition of endothelin contraction in porcine retinal arterioles
AK Winther, T Dalsgaard, ER Hedegaard, U Simonsen - Nitric Oxide, 2015 - Elsevier
Perivascular retina has been shown to regulate retinal vascular tone. In the present study, we
evaluated an ex vivo retina preparation, and investigated whether hydrogen sulfide (H 2 S) …
evaluated an ex vivo retina preparation, and investigated whether hydrogen sulfide (H 2 S) …
Mechanisms involved in increased sensitivity to adenosine A2A receptor activation and hypoxia-induced vasodilatation in porcine coronary arteries
ER Hedegaard, BD Nielsen, S Mogensen… - European journal of …, 2014 - Elsevier
Hypoxia-induced coronary vasorelaxation is a compensatory mechanism increasing blood
flow. We hypothesized that hypoxia shares pathways with adenosine and causes …
flow. We hypothesized that hypoxia shares pathways with adenosine and causes …
[HTML][HTML] Down-regulation of KCa2.3 channels causes erectile dysfunction in mice
…, ER Hedegaard, S Mogensen, C Aalkjaer, R Köhler… - Scientific Reports, 2017 - nature.com
Modulation of endothelial calcium-activated K + channels has been proposed as an
approach to restore arterial endothelial cell function in disease. We hypothesized that small-…
approach to restore arterial endothelial cell function in disease. We hypothesized that small-…